Table 3.

Structural and/or functional domains within Cdc42 regulators and effectors

DomainaFunctionRegulator or effector
CRIB (also PBD, GBD, PAK)Binding to Cdc42p effector domainPAK, ACK, Gek, MIHCK, MLK3, and MEKK4 kinases; Gic1; Gic2; WASPs; N-WASP
CHBinding to actinIqg1/Cpk1, IQGAPs
DHGEF catalytic domainGEFs
FH1, FH2Binding to profilin, myosinBni1, Bnr1, formins
GRDBinding to Cdc42pIqg1/Cpk1, IQGAPs
IQ (Ile and Gln residues)Binding to calmodulinIqg1/Cpk1, IQGAPs, N-WASP
LIMProtein-protein interactionsRga1, Rga2
PDZProtein-protein interactionsSif, DRhoGEF2
PHMembrane localization and protein-protein interactionsGEFs, Bem3, CeGAP, Cla4, Skm1, Pak2, Gek, Bee1, WASPs, N-WASP, Boi1, Boi2
SH3Binding to proline-rich domainsMyo3, Myo5, Bem1, Boi1, Boi2, Scd2, DrtGEF
  • ↵a CRIB, Cdc42/Rac interactive binding; CH, calponin homology; DH, Dbl homology; FH1, FH2, formin homology 1, 2; GRD, GAP-related domain; PH, pleckstrin homology; SH3, src homolog 3.