Table 1.

Caspase substrates

Substrate
Cell death proteins
 Bcl-2
 Bcl-xL
 Bid
 CrmA
 IAP
 p28 Bap31
 p35
 Procaspases
Cell cycle regulation
 Cdc27
 Cyclin A
 MDM2
 p21 (Cip1/Waf1)
 p27 (Kip1)
 PITSLRE kinases
 Retinoblastoma protein
 Wee1 phosphatase
Cytoskeleton
 Actin
 β-Catenin
 Fodrin
 Gas2
 Gelsolin
 Keratin-18 and -19
 Lamins
 Plakoglobin
Cytokine precursors
 Pro-IL-1β
 Pro-IL-16
 Pro-IL-18 (IGIF)
DNA metabolism
 Acinus
 DNA-dependent protein kinase (DNA-PK)
 DNA replication complex C (DSEB/RFC140)
 ICAD
 MCM3 DNA replication factor
 NuMA
 PARP
 Topoisomerase 1
Neurodegenerative disease proteins
 APP
 Ataxin-3 (spinocerebellar ataxia type 3)
 Androgen receptor (Kennedy's disease)
 Atrophin-1 (dentarorubral pallidoluysian atrophy protein
 Huntingtin
 Presenilins
RNA metabolism
 Eukaryotic initiation factor 2α
 Heteronuclear ribonuclear proteins C1 and C2
 70-kDa U1-snRNP
Signal transduction
 Adenomatous polyposis coli protein (APC)
 Akt/PkB
 Calmodulin-dependent kinase IV
 c-Raf
 D4-GDP dissociation inhibitor
 Fyn tyrosine kinase
 Focal adhesion kinase
 MEKK1
 MST/Ksr
 PAK-2/hPAK65
 Protein kinase C delta
 Protein kinase C theta
 Protein kinase C-related kinase 2
 Protein phosphatase 2A
 Ras GTPase activating protein
 TCR-ζ chain
Transcription factors
 Heat shock factor
 GATA-1
 IκB-α
 NF-κB (p50, p65)
 NRF-2
 Sp1
 STAT1
 Sterol-regulatory element-binding proteins
Others
 Calpastatin
 Hsp90
 Nedd4
 Phospholipase A2
 Rabaptin-5
 Transglutaminase