Table 7.

Reported drug resistance profiles of PMF- and ATP-dependent multidrug transportersa

DrugMFSSMRRNDMATEABC
12-TMS cluster14-TMS cluster
BcrBltBmrCmrEmrDLmrPMdfANorAPmrATapBmr3EmrBLfrAQacAQacBVceBEbrABEmrEMmrQacEQacEΔ1QacGQacHSmrTehAYkkCDAcrBAcrFAmrBHI0895MexBMexDMexFMexYMtrDYhiVNorMYdhEHorALmrA
Aminoglycosides+b +++c +++
β-Lactams
 Carbapenems+
 Cephalosporins++
 Penicillins+++d ++
Chloramphenicol+++++++++++
Glycopeptides+
Lincosamides++
Macrolides
 14-Membered+++++++++++++++
 15-Membered++++
 16-Membered
Novobiocin+++++++
Quinolones
 Hydrophilic++e ++e ++++++++++
 Hydrophobic+e +e +++++++
Rifampin++++++++
Sulfonamides++
Tetracyclines++++f ++++++++++
Trimethoprim++
  • a +, resistance; −, no resistance.

  • b MdfA expression confers resistance to kanamycin and neomycin but hypersusceptibility to spectinomycin.

  • c MexCD expression confers hypersusceptibility to carbenicillin but does not affect resistance to ampicillin and penicillin.

  • d MexCD expression confers hypersusceptibility to gentamicin.

  • e Bmr and NorA confer a higher level of resistance to hydrophilic quinolones than to hydrophobic quinolones.

  • f LfrA confers resistance to tetracycline but not to minocycline and chlortetracycline.