Table 6.

Examples of horizontally transferred genes in D. radiodurans

ProteinGene nameTaxons where homologs are foundBest BLAST hit: species, gene identifier, and e-valueComments
Topoisomerase IBDR0690 Eucaryaand double-stranded DNA virusesOrf virus, gil521138, 2 × 10−11 Belongs to eukaryotic type I topoisomerases; performs ATP-independent breakage of single-stranded DNA, followed by passage and rejoining; the first finding of a topoisomerase of this family in bacteria
Yellow protein (Drosophila) or royal jelly protein (honeybee)DR1790 Insecta Drosophila subobscura, gil2222667, 1 × 10−14 Required for cuticular pigmentation in Drosophila and important component of royal jelly of honeybee
Acyl coenzyme A-binding protein (ACBP)DR0166 Eucarya Caenorhabditis elegans, gil2088729, 2 × 10−17 Binds medium- and long-chain acyl coenzyme A esters with very high affinity
Ro RNA-binding proteinDR1262 Eucarya Xenopus laevis, gil1173109, 4 × 10−86 Ribonucleoproteins complexed with several small RNA molecules; involved in UV-resistance in Deinococcus
LEA14-like desiccation-induced proteinDR1372 Plantae andArchaea Lycopersicon esculentum, gil1684830, 1 × 10−3 Protein induced in leaves by desiccation, ethylene, or abscisic acid
Desiccation-induced proteinDRB0118 Craterostigma plantagineum(plants) Craterostigma plantagineum, gil118926, 4 × 10−19 Protein induced in leaves by desiccation or abscisic acid
LEA76/LEA26-like desiccation-induced proteinDR1172 Eucarya (mostly plants) C. elegans, gil2353333, 2 × 10−26 In plants, protein induced in leaves by desiccation, ethylene, or abscisic acid
Protein kinase of RIO1 familyDR2209 Eucarya andArchaea Schizosaccharomyces pombe, gil2661615, 1 × 10−12 Protein kinase SudD, RIO1 family member, is a suppressor of bimD genes, which are involved in cell cycle control in Emericella nidulans
PeroxidaseDRA0145 Polyporaceae spp. (fungi) Polyporaceae spp., gil2160705, 4 × 10−34
Tryptophan-2,3-dioxygenaseDRA0339 Eucarya Drosophila simulans, gil881370, 5 × 10−18 Convertsl-tryptophan to l-formylkynurenine; binds heme; can utilize other substrates
l-Kynurenine hydrolaseDRA0338Orthologs only inEucarya Saccharomyces cerevisiae, gil1532216, 4 × 10−37 Belongs to pyridoxal-dependent aminotransferase family; hydrolyzes l-kynurenine to anthranilate and l-alanine
Serine carboxypeptidaseDR0964 Eucarya Homo sapiens, >gil2098347, 9 × 10−7
Tungsten formylmethanofuran dehydrogenase, subunit E (FwdE)DRA0267 Archaea Pyrococcus horikoshii, >gil3257655, 2 × 10−13 Involved in methanogenesis; operon encoding all subunits of this enzyme contains six genes, fwdEFACDB, most of which are absent in this genome
Homolog of a tymocyte protein cThy28kDDR0566 Eucarya, Archaea, and cyanobacteria Synechocystis spp., gil1653325, 2 × 10−28 Bacterial proteins show significantly greater similarity to each other and to eukaryotic homologs than to archaeal homologs, which suggests horizontal transfer between bacteria and eukaryotes
Uncharacterized proteinDR0376Cyanobacteria andAquifecales Synechocystis spp., gil2708801, 4 × 10−44 Probable enzymatic domain with a conserved glutamate; Synechocystis encodes at least 35 proteins of this family; Deinococcus has 3 of them