Table 4.

Relative amino acid compositions of mesophilic and hyperthermophilic proteinsa

Residue(s)Amino acid composition (%) of:Variation of composition in hyperthermophilic relative to mesophilic proteins
Mesophilic proteinsbHyperthermophilic proteinsc
A8.09 ± 1.546.82 ± 1.42−1.27
C1.10 ± 0.180.86 ± 0.27−0.24
D5.06 ± 0.184.63 ± 0.54−0.43
E6.45 ± 0.548.55 ± 0.95+2.10
F4.61 ± 0.784.40 ± 0.82−0.21
G6.70 ± 0.967.16 ± 0.68+0.46
H2.04 ± 0.211.57 ± 0.16−0.47
I7.40 ± 1.697.82 ± 1.64+0.42
K6.81 ± 2.007.61 ± 2.16+0.80
L10.43 ± 0.5510.21 ± 0.68−0.22
M2.42 ± 0.282.29 ± 0.25−0.13
N4.90 ± 1.203.52 ± 0.94−1.38
P3.77 ± 0.774.36 ± 0.99+0.59
Q3.99 ± 0.751.78 ± 0.22−2.21
R4.33 ± 0.985.57 ± 1.16+1.24
S6.08 ± 0.575.54 ± 1.01−0.54
T5.09 ± 0.574.34 ± 0.23−0.75
V6.35 ± 0.758.05 ± 0.68+1.70
W1.02 ± 0.311.06 ± 0.20+0.04
Y3.30 ± 0.433.82 ± 0.33+0.52
A, G14.7913.98−0.81
D, E11.5113.18+1.67
K, R, H13.1814.75+1.57
S, T11.17 9.88−1.29
N, Q 8.99 5.3 −3.69
I, L, M, V26.6028.37+1.77
F, W, Y 8.93 9.28+0.35
  • a Data from references 81,175, and GenBank.

  • b From the genome sequences of B. subtilis, Campylobacter jejuni, E. coli, Haemophilus influenzae, Helicobacter pylori, Neisseria meningitidis, Rickettsia prowazekii, and Synechocystis.

  • c From the genome sequences of A. fulgidus, A. aeolicus, A. pernix, M. jannaschii, P. abyssi, P. horikoshii, and T. maritima.