Table 6.

Current applications of the tetracyclines for therapy and prophylaxis of human infectionsa

Infection for which tetracyclines are:
First choice Acceptable alternative to other agentsb
 Atypical pneumonia due to Mycoplasma pneumoniae, Chlamydia pneumoniae, C. psittaciCommunity-acquired pneumoniac
Infective exacerbations of chronic bronchitisc
Legionellosis (doxycycline)
 Prophylaxis of traveler's diarrhea
 Nongonococcal urethritis Syphilis
 Cervicitis Epididymitis
 Lymphogranuloma venereum Prostatitis
 Pelvic inflammatory disease
 Granuloma inguinale
Local and systemic
 Rocky mountain spotted fever MRSA
 Endemic and epidemic typhus MRSE (minocycline) when vancomycin or other agents inappropriate
 Q fever Plague
 Brucellosis (in combination with rifampin or streptomycin)Tularerira
 Lyme disease Bartonellosis
 Relapsing feverLeptospirosis
 Periodontal infection (topical therapy with tetracycline or minocycline) Whipple's disease Cutaneous infections caused by Mycobacterium marinum and in multiple-drug regimens for ocular infections caused by M. cheloni
 Acne vulgaris (topical and systemic treatment)
Gastritis caused byHelicobacter pylori (tetracycline in multiple-drug regimens).
 Prophylaxis of mefloquine-resistantPlasmodium falciparum malaria
  • a Based on information from references3, 73, 79, 88, 107, 118, 131, 171, 275, 301, 303, 305, and313.

  • b MRSA, methicillin-resistantStaphylococcus aureus; MRSE; methicillin-resistantStaphylococcus epidermidis.

  • c Except in situations where there is a high rate of resistance among pneumococci and/or H. influenzae.