Table 5.

Distribution of tetracycline resistance genes among gram-positive bacteria, Mycobacterium, Mycoplasma, Nocardia, Streptomyces, and Ureaplasmaa

One determinantTwo determinantsThree or more determinants
Genus Gene Genus Genes GenusGenes
Abiotrophia tet(M) Actinomyces tet(L), tet(M) Eubacteriumb tet(K),tet(M), tet(Q)
Bacterionema tet(M) Aerococcus tet(M),tet(O) Bacillus tet(K),tet(L), tet(M)
Gemella tet(M) Bifidobacteriumb tet(M), tet(W) Listeria tet(K), tet(L), tet(M),tet(S)
Mycoplasmac tet(M) Gardnerella tet(M),tet(Q) Staphylococcus tet(K),tet(L), tet(M), tet(O)
Ureaplasmac tet(M) Lactobacillus tet(O), tet(Q) Clostridiumb tet(K),tet(L), tet(M), tet(P),tet(Q)
Nocarida tet(K) Mobiluncusb tet(O),tet(Q) Peptostreptococcusb tet(K), tet(L), tet(M),tet(O), tet(Q)
Corynebacterium tet(M),tet(Z) Enterococcus tet(K),tet(L), tet(M), tet(O),tet(S), tet(U)
Streptococcus tet(K),tet(L), tet(M), tet(O),tet(Q), tet(T)
Mycobacteriumd tet(K), tet(L), tet(V),otr(A), otr(B)
Streptomycese tet(K), tet(L), otr(A),otr(B), otr(C), tcr3f, tetf
  • a Based on information from references12, 13, 26, 27, 33-38, 45, 47, 48, 62-66, 69, 74-76, 84, 85,93, 96, 98, 103, 105, 108, 138a, 139, 140, 143, 150-153, 162, 164,183, 184, 188, 200, 201, 206, 207, 209, 210, 212, 213, 220, 222,225-230, 235-238, 242-245, 255, 273, 290, 297, and 307; and M. Roberts, unpublished results.

  • b Anaerobic species.

  • c Cell-wall-free bacteria with a gram-positive metabolism.

  • d Acid-fast bacteria.

  • e Multicellular bacteria.

  • f tet and tcr have not been given number designations.