Table 5.

Distribution of tetracycline resistance genes among gram-positive bacteria, Mycobacterium, Mycoplasma, Nocardia, Streptomyces, and Ureaplasmaa

One determinantTwo determinantsThree or more determinants
Genus Gene Genus Genes GenusGenes
Abiotrophiatet(M) Actinomycestet(L), tet(M)Eubacteriumbtet(K),tet(M), tet(Q)
Bacterionematet(M) Aerococcustet(M),tet(O) Bacillustet(K),tet(L), tet(M)
Gemellatet(M) Bifidobacteriumbtet(M), tet(W) Listeriatet(K), tet(L), tet(M),tet(S)
Mycoplasmactet(M) Gardnerellatet(M),tet(Q) Staphylococcustet(K),tet(L), tet(M), tet(O)
Ureaplasmactet(M)Lactobacillustet(O), tet(Q)Clostridiumbtet(K),tet(L), tet(M), tet(P),tet(Q)
Nocaridatet(K)Mobiluncusbtet(O),tet(Q) Peptostreptococcusbtet(K), tet(L), tet(M),tet(O), tet(Q)
Corynebacteriumtet(M),tet(Z) Enterococcustet(K),tet(L), tet(M), tet(O),tet(S), tet(U)
Streptococcustet(K),tet(L), tet(M), tet(O),tet(Q), tet(T)
Mycobacteriumdtet(K), tet(L), tet(V),otr(A), otr(B)
Streptomycesetet(K), tet(L), otr(A),otr(B), otr(C), tcr3f, tetf
  • a Based on information from references12, 13, 26, 27, 33-38, 45, 47, 48, 62-66, 69, 74-76, 84, 85, 93, 96, 98, 103, 105, 108, 138a, 139, 140, 143, 150-153, 162, 164, 183, 184, 188, 200, 201, 206, 207, 209, 210, 212, 213, 220, 222, 225-230, 235-238, 242-245, 255, 273, 290, 297, and 307; and M. Roberts, unpublished results.

  • b Anaerobic species.

  • c Cell-wall-free bacteria with a gram-positive metabolism.

  • d Acid-fast bacteria.

  • e Multicellular bacteria.

  • f tet and tcr have not been given number designations.