Table 1.

Principal members of the tetracycline class

Chemical name Generic name Trade name Yr of discovery Status Therapeutic administration
7-ChlortetracyclineChlortetracycline Aureomycin1948 Marketed Oral
5-Hydroxytetracycline Oxytetracycline Terramycin 1948Marketed Oral and parenteral
Tetracycline TetracyclineAchromycin 1953 Marketed Oral
6-Demethyl-7-chlortetracycline DemethylchlortetracyclineDeclomycin 1957 Marketed Oral
2-N-Pyrrolidinomethyltetracycline RolitetracyclineReverin 1958 Marketed Oral
2-N-Lysinomethyltetracycline LimecyclineTetralysal 1961 Marketed Oral and parenteral
N-Methylol-7-chlortetracycline Clomocycline Megaclor1963 Marketed Oral
6-Methylene-5-hydroxytetracyclineMethacycline Rondomycin 1965 Marketed Oral
6-Deoxy-5-hydroxytetracycline Doxycycline Vibramycin1967 Marketed Oral and parenteral
7-Dimethylamino-6-demethyl-6-deoxytetracycline MinocyclineMinocin 1972 Marketed Oral and parenteral
9-(t-butylglycylamido)-minocyclineTertiary-butylglycylamidominocycline Tigilcycline 1993Phase II clinical trials