TABLE 2.

Acid-tolerant mutants of L. lactis MG1363 identified by Rallu et al. (189)

MutantInsert locationPutative functionaClassOther informationb
arl12 glnH Amino acid ABC transporter (binding)2
arl13 glnP Amino acid ABC transporter (permease)2
arl11Putative glnP-glnQ intergenic region2
arl14 glnQ Amino acid ABC transporter (ATP binding)1
arl15 yzmB (pstS) ribosome-binding sitePhosphate ABC transporter (binding)1Ox+++
arl16 yzmE (pstB)Phosphate ABC transporter (ATP binding)3
arl17 hpt Purine salvage4Ox+/Heat+/CS+
arl18 relA (p)ppGpp synthetase4Ox+/Heat+/CS+
arl19, arl20 guaA Purine biosynthesis4Ox+/Heat+/CS+
arl21, arl22 deoB promoterPurine and pyrimidine salvage3Heat+
arl23 recN DNA metabolism3Heat+
arl8, arl10 yybT No homology4
arl1No homology3Ox+++
arl2No homology3Ox+
arl3No homology2
arl4Upstream of putative glnU promoterNo homology3Ox+
arl5No homology4Heat+/CS+
arl7No homology (purine metabolism?)4Heat+/CS+
  • a ABC, ATP, binding cassette.

  • b Ox+, increased survival in the presence of oxidative stress; Ox+++, greatly increased survival in the presence of oxidative stress; Heat+, increased survival in the presence of heat stress; CS+, increased resistance to carbon starvation.