TABLE 2.

C. albicans SAP genes and deduced proteinsa

GenePrepropeptide size (aa)cNo. of KR and KK sitesbORF size (bp)cMature enzyme size (aa)cNo. of N-glycosylation (propeptide) sitesdChromosomedReference
SAP1 502 KR1,1733411 (0)6 101
SAP2 562 KR1,1943420 (2)R 250
SAP3 581 KR1,1943401 (1)3 247
SAP4 754 KR1,2543420 (1)6 144
SAP5 764 KR1,2543420 (0)6 147
SAP6 764 KR1,2543420 (1)6 147
SAP7 2111 KK1,7643771 (4)1 147
SAP8 732 KR1,2154051 (1)3 146
SAP9 501 KR, 1 KK1,6325444 (0)3 146
SAP10 381 KR1,3264038 (0)4 66
  • a Reprinted from reference 98 with permission.

  • b All Sap proteins contain Lys/Arg (KR)- or Lys/Lys (KK)-processing sites and four conserved cysteine residues.

  • c The sizes of the prepropeptide (signal peptide and propeptide) and the mature enzyme are shown in amino acids (aa), and the size of the open reading frame (ORF) is shown in base pairs.

  • d The number of potential N-glycosylation sites, including those located in the propeptide (in parentheses), and the chromosomal location of the gene are also shown. Sap9 and 10 have structural elements typical of GPI proteins (27).