TABLE 23.

DNA damage checkpoint genes

S. cerevisiae geneFunctionNeurospora homologueContigE valueBest match to Neurospora protein in SP + TrEMBLE value (BLASTP)
RAD17DNA damage checkpoint, control protein, 3′-5′ exonuclease (putative)NCU00942.13.379e-05Xenopus RAD19e-17
M. musculus REC14e-16
S. pombe Rad15e-15
S. cerevisiae Rad170.009
MEC1DNA damage checkpoint, inositol/phosphatidylinositol kinase activityNCU00625.1 mus-93.23e-135E. nidulans UVSB0.0
S. pombe Rad30.0
Human ATRe-146
S. cerevisiae Mec1e-130
DPB11S-phase checkpoint, epsilon DNA polymerase activityNCU09503.13.6108e-04S pombe Rad42e-55
Human KIAA02596e-15
S. cerevisiae Dpb111e-08
S. pombe rad9+Cell cycle checkpointNCU00470.13.152e-18S pombe Rad95e-16
S. octosporus homolog7e-16
Human RAD9 homolog5e-09
RAD24DNA damage checkpoint, DNA clamp loader activityNCU00517.13.182e-22M. musculus RAD177e-2
Green monkey RAD172e-22
Human RAD173e-22
S pombe Rad172e-14
S. cerevisiae Rad241e-09
E. nidulans uvsD (DDC2/PIE1/LCD1)DNA damage checkpoint, damaged DNA binding activity, protein binding activityNCU09644.1 uvs-33.6278e-30E. nidulans UVSD4e-22
CHK1DNA damage checkpoint, protein kinase activityNCU08346.1 un-13.5012e-68S. pombe Chk11e-82
S. cerevisiae Chk15e-63
Human CHK13e-43
RAD9DNA damage checkpoint, protein binding activityNCU08879.13.5531e-06S. pombe RHP91e-12
Leishmania PPG32e-07
S. cerevisiae Rad96e-05
RAD53/MEC2/SPK1/LSD1DNA repair, protein threonine/ tyrosine kinaseNCU02751.13.1406e-50S. cerevisiae Rad531e-46
S. pombe Cds14e-36
Human CAMK12e-32
DUN1DNA damage checkpoint, protein kinase activityNCU02814.13.1469e-72S. cerevisiae Dun17e-72
Human CHK22e-71
S. pombe hus1+DNA damage checkpoint, DNA binding activityNCU03820.13.2038e-30A. nidulans NUV1012e-56
S. pombe Hus19e-44
M. musculus HUS11e-10
TEL1Response to DNA damage, inositol/phosphatidylinositol kinase activityNCU00274.1 mus-213.12e-112S. pombe Telle-158
Xenopus ATMe-116
Human ATMe-104
S. cerevisiae Tel15e-97
PTC2DNA damage checkpoint, protein phosphatase type 2C activityNCU04600.13.2392e-79S. pombe Ptc2e-121
S. pombe Ptc3e-117
S. cerevisiae Ptc34e-79
Human PPM1A4e-51
RFX1/CRT1DNA damage checkpoint, specific transcriptional repressor activityNCU06701.13.3876e-29Cephalosporium CPCR1e-169
Penicillium RFX1e-102
S. cerevisiae Rfx12e-36
Human RFX12e-30
ASF1Histone binding, DNA damage response, signal transductionNCU09436.13.6028e-65S. cerevisiae Asf11e-61
S. pombe Cia12e-54
Human HSPC1462e-45