TABLE 36.

Homocysteine and methionine metabolism

EnzymeEC no.NCU no.BLAST match
Best overallS. cerevisiaeS. pombeAnimalaPlantb
Cystathionine γ-synthase2.5.1.4808117.1S. pombe SPBC1504.09c/1e-421e-291e-42c
Cystathionine γ-synthase2.5.1.4805093.1P. anserina CAC6069/2e-501e-432e-29
Cystathionine γ-synthase (MET-7)2.5.1.4802430.1P. anserina Pa5D0012/0.07e-921e-1313e-161e-15
Homoserine dehydrogenase1.1.1.303935.1S. pombe SPBC776.03/1e-864e-851e-861e-70
Homoserine O-acetyltransferase (met-5)2.3.1.3107001.1A. nidulans MetE/0.02e-1429e-147
Cystathionine β-lyase (MET-2)4.4.1.807987.1B. fuckeliana meC/0.02e-973e-813e-741e-100
Methionine synthase (MET-8)2.1.1.1306512.1A. nidulans MetH/D/0.00.00.01e-950.0
Methionine synthase2.1.1.1308434.1R. palustris ZP8831/8e-44
Methionine synthase2.1.1.1310020.1R. palustris ZP8831/8e-44
O-Acetyl-homoserine sulfhydrolase (bifunctional)2.5.1.4901652.1A. nidulans CysA/0.0e-1412e-1489e-431e-39
Folyl polyglutamate synthase (met-6)6.3.2.1700892.1S. cerevisiae Met7p/4e-1044e-1044e-981e-753e-60
Folyl polyglutamate synthase6.3.2.1701337.1S. cerevisiae Fo13p/5e-655e-653e-642e-294e-27
Serine hydroxymethyl transferase (for)2.1.2.102274.1C. albicans SHM2/0.00.00.04e-1511e-153
Glycine hydroxylmethyl transferase2.1.2.105805.1S. pombe Shm2/3e-1683e-1643e-1681e-1533e-167
5,10-Methylene tetrahydrofolate reductase (MET-1)4.2.1.2207690.1S. pombe MTHFR2/4e-1743e-1684e-1741e-1354e-138
5,10-Methylene tetrahydrofolate reductase4.2.1.2209545.1S. cerevisiae Met12p/8e-1438e-1432e-1423e-839e-94
SAM synthetase (ETH-1)2.5.1.606512.1S. pombe Sam1/1e-155e-1451e-1552e-1414e-118
SAM:3-amino-3-carboxylpropyl transferase2.5.1.-03032.1R. sphaeroides btaA/2e-18
Adenosyl homocysteinase3.3.1.107930.1S. cerevisiae Sah1p/0.00.00.01e-805e-142
Cystathionine β-synthase4.2.1.2208216.1M. grisea CBS1/0.01e-1182e-475e-1075e-49
Cystathionine γ-lyase (CYS-16)4.4.1.109230.1A. chrysogenum MecB/3e-1782e-1295e-444e-961e-65
  • a Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, or Homo sapiens.

  • b Arabidopsis thaliana or Oryza sativa.

  • c Values below e-10 are represented as —.