TABLE 55.

Comparison of fungal motor proteins

NCU no.Orthologue(s)Family/classProposed role(s)
S. cerevisiaeS. pombe
Kinesins
    09730.1Smy1pKlp3 (SPAC1834.07)Conventional kinesinTransport of secretory(?) vesicles, nuclear positioning, microtubule dynamics
    06733.1NFaNFUnc104Vesicular transport
    03715.1NFSPAC144.14
    06832.1NFNFKif21/chromokinesinVesicular transport, DNA binding
    04581.1Kar3pPkl1/Klp1 (SPAC3A11.14C)C-terminalDyanamics if spindle microtubules, counteracts BimC-like motors
Klp2 (SPAC664.10)
    06144.1Kip3pKlp5 (SPBC2F12.13)Kip3Spindle positioning, spindle elongation during anaphase, microtubule disassembly
Klp6 (SPBC649.01C)
    00927.1Kip1p, Cin8pCut7 (SPAC25G10.07C)BimC/Eg5Spindle assembly and centrosome separation during mitosis
    05180.1NFSPBC15D4.01C (also named SPBC2D10.21C)Fast evolving/pavarottiOrganization of the mitotic spindle
    02626.1Kip2pKlp4/Tea2 (SPBC1604.20C)Kip2Heterogenous group: Kip2p has mitotic functions (partly overlapping with Kip3p), while Tea2 seems to alter the dynamics of interphase microtubules
    05028.1NFNFKIDChromosome alignment in metaphase
Myosins
    01440.1Myo2p, Myo4pMyo5 (SPCC1919.10c)Class VOrganelle transport
Myo4 (SPBC2D10.14c)
    02111.1Myo3p, Myo5pMyo1 (SPBC146.13c)Class IEndo-/exocytosis
    00551.1Myo1pMyo2 (SPCC645.05c)Class IIActin organisation, cytokinesis
Myo3 (SPAC4A8.05c)
    04350.1NFNFChitin sythase-myosin fusion proteinSpecific for filamentous fungi
Dynein subunitsNuclear movement, spindle elongation, retrograde vesicle transport
    06976.1Dyn1pDhc1Dynein heavy chain
    09142.1Pac11pSPBC646.17Dynein intermediate chain
    09982.1NFNFDynein light intermediate chain
    02610.1Dyn2pDlc (SPAC926.07)Dynein light chain, LC8
    03882.1NFDlc (SPAC1805.08)Dynein light chain, Tctex-1
    09095.1NFNFDynein light chain, LC7
Dynactin subunitsDynein-cargo interaction, nuclear movement, spindle elongation, retrograde vesicle transport
    03483.1NIP100pNFDynactin p150Glued
    00257.1NFNFDynactin p62
    03563.1NFNFDynactin Arp11
    08375.1NFNFDynactin p50/dynamitin
    04247.1Arp1pActin-like protein (SPBC1347.12)Dynactin Arp1
    04043.1NFNFDynactin p27
    07196.1NFNFDynactin p25
    Not definedNFNFDynactin p24
Lis-1 complexDynein regulation, nuclear movement, spindle elongation, retrograde vesicle transport
    04534.1Pac1pNFLIS1
    04312.1Pac1pNFLIS1
    08566.1NFNFNUDE/RO11
  • a NF, not found by conventional BLAST searches.