Known and predicted N. crassa proteins associated with circadian clocks and photobiology
Protein class | Neurospora protein | Function | NCU no. | BLAST match | ||||
---|---|---|---|---|---|---|---|---|
Best overall | S. cerevisiae | S. pombe | Animala | Plantb | ||||
Clock-associated genes | FRQ | N. crassa central clock component | 02265.1 | Sordaria fimicola; e 0.0 | None | None | None | None |
WC-1 | N. crassa blue-light photoreceptor, central oscillator component, 2 PAS domains, 1 LOV domain, GATA zinc finger domain | 02356.1 | Podospora anserina; e 0.0 | Ymr1369; e-06 | SPCC1902.01; 5e-05 | Drosophila; e-14 | NP851210.1; 4e-18 | |
WC-2 | Forms complexes with WC-1, central oscillator component and blue-light signaling, 1 PAS domain, GATA zinc finger domain | 00902.1 | Fusarium solani; e-138 | Ymr136W; 6e-08 | None | None | AC026875.23; 3e-07 | |
CKA | N. crassa casein kinase II catalytic subunit involved in FRQ | 03124.1 | Candida albicans; e-148 | YorR061W CKA2; e-106 | SPAC23C11 CKII; e-130 | P28020; e-105 | AF370308; e-112 | |
CKB1 | N. crassa casein kinase II regulatory subunit involved in FRQ phosphorylation | 05485.1 | S. pombe; 4e-61 | Yg109W CKB1; e-53 | SPBC2G5.02C CKII; 4e-61 | P28021; 3e-46 | AF239816; 4e-41 | |
CKB2 | N. crassa casein kinase II regulatory subunit involved in FRQ phosphorylation | 02754.1 | S. pombe; 2e-77 | Y1r039C RIC1; 8e-4 | SPAC1851.04e; 2e-77 | XP317865.1; 2e-60 | NP181996.1; 1e-58 | |
HHP1 | N. crassa casein kinase I involved in FRQ phosphorylation | 00685.1 | S. pombe; e-150 | NP015120.1; e-125 | NP595760.1; e-150 | BAB0347 3.1; e-135 | BAB92346.1; e-130 | |
CAMK | N. crassa protein kinase involved in FRQ phosphorylation | 09123.1 | Aspergillus nidulans; 1e-165 | Yoi016C CMK2; e-99 | SPACUNK12.02c; 4e-67 | NP065130.1; 2e-69 | NP192383.1; 8e-49 | |
SHAGGY/GSK-3 homologue | Drosophila protein kinase Shaggy involved in phosphorylation and nuclear movement of the central oscillator component TIM | 04185.1 | Colletotrichum gloeo- sporioides; e-157 | Ymi139W Rim11; e-104 | SPAC1687.15; e-148 | NP571465; e-130 | AF43225.1; e-119 | |
FWD-1 | E3 ubiquitin ligase involed in targeting FRQ for proteasomal turnover | 04540.1 | Homo sapiens; e-47 | None | SPAC30.05; e-40 | Homo sapiens; e-47 | None | |
Other light- sensing genes | VVD | N. crassa blue-light sensing, PAS/LOV domain | 03967.1 | Aspergillus nidulans; 2e-41 | None | None | None | BAA84780.1; 3e-19 |
PHY-1 | Putative phytochrome red/far-red-light sensing | 04834.1 | Pseudomonas putida; 8e-61 | Ylu206W; 3e-09 | SPAC27E2.09; 2e-27 | None | P55004; 4e-33 | |
PHY-2 | Putative phytochrome red/far-red-light sensing | 05790.1 | Agrobacterium tumefaciens; 2e-33 | Yi1147C SLN1; 8e-9 | SPAC1834.08; 2e-14 | None | P55004; 2e-21 | |
CRY homolog | Putative blue-light sensing, central oscillator component in mammals, light entrainment of the clock in Drosophila | 00582.1 | Trichodesmium erythraeum; 4e-69 | Yoi386w PHR1; 4e-26 | None | None | NP58461.2; 2e-49 | |
VELVET homologue | Red- and blue-light sensing in Aspergillus | 01731.1 | Aspergillus nidulans; 5e-40 | None | None | None | None | |
NOP-1 | Neurospora homologue of bacteriorhodopsin | 10055.1 | Leptosphaeria maculans opsin; 2e-75 | Yro2p; e-08 | SPCC31H12.02c; 9e-07 | None | None | |
ORP-1 | Neurospora opsin-related protein, lacks conserved lysine residue | 01735.1 | Coriolus versicolor Hsp30; 5e-31 | Yro2p; 8e-23 | SPCC31H12.02c; 8e-12 | None | None | |
Other PAS proteins | Hypothetical protein | 4 PAS domains, sensory box histidine kinase/response regulator | 03164.1 | Shewanella oneidensis; 6e-31 | Yi1147C SLN1; 2e-10 | SPAC27E2.09; 1e-20 | None | None |
Predicted protein | 3 PAS domains | 06390.1 | Caenorhabditis elegans; e1.4 | None | None | None | None | |
PAS/PAC domain proteins | Hypothetical protein | PAS/PAC domain 1e-88, sensory transduction histidine kinase | 02057.1 | Magnetococcus sp. strain MC-1; 4e-75 | Yi1147C SLN1; 4e-18 | SPAC183 4.08; 6e-57 | None | None |
Hypothetical protein | PAS/PAC domain 3e-59, two-component hybrid sensor and regulator | 00939.1 | Anabaena sp. strain PCC 7120; 4e-23 | Yi1147C SLN1; 6e-11 | SPAC27E2.09; 2e-25 | None | None | |
Hypothetical protein | PAS/PAC domain 3e-63, putative two-component histidine kinase Fos-1 | 07221.1 | Aspergillus fumigatus; e-161 | Yi1147C SLN1; 7e-17 | SPAC27E2.09; 3e-36 | None | None | |
Hypothetical protein | PAS/PAC domain 3e-88, related to two-component histidine kinase chk-1 | 01833.1 | Glomerella cingulata; 0.0 | Ylu206W; e-10 | SPAC1834.08; 8e-79 | None | None | |
Hypothetical protein | PAS/PAC domain 5e-42, probable serine/threonine protein kinase, related to plant NPH-1 protein | 07268.1 | Caulobacter crescentus; 2e-07 | None | None | None | T013535; e-07 |