TABLE 40.

Lipid metabolism

EnzymeEC no.NCU no.BLAST match
Best overallS. cerevisiaeAnimalPlant
Fatty acid synthesis
    Acetyl-CoA carboxylase6.4.1.208535.10.0; E. nidulans0.0
    Fatty acid synthase (alpha)2.3.1.8507308.10.0; E. nidulans0.0
    Fatty acid synthase (beta)2.3.1.8607307.10.0; E. nidulans0.0
    Fatty acid elongase2.3.1.4106694.14e-75; S. pombe4e-73
Fatty acid desaturation
    Fatty acid hydroxylase1.14.15.03492.11e-93; S. cerevisiaeBest match3e-33; M. musculus8e-35; O. sativa
    Stearoyl-CoA desaturase1.14.99.505259.10.0; Ajellomyces capsulatus8e-121
    Oleate Δ12 desaturase1.14.99.02209.1e-180; E. nidulans5e-12e-80; S. oleracea
    Oleate Δ12 desaturase1.14.99.09497.11e-78; A. parasiticus3e-11e-68; S. oleracea
    Fatty acid Δ6 desaturase1.14.19.102408.10.0; P. anserina2e-37e-54; T. aestivum
Fatty acid degradation
    Multifunctional beta-oxidation protein1.1.1.3508828.10.0; Y. lipolytica0.0e-141; H. sapiens2e-52; A. thaliana
5.1.2.
4.2.1.17
Acyl group transfer
    Glycerol-3-phosphate acyltransferase2.3.1.1505985.1e-150; S. pombee-132
    Lysophosphatidic acid acyltransferase2.3.1.-00168.12e-71; E. nidulans1e-443e-24; M. musculus
    Diacylglycerol acyltransferase2.3.1.2002665.12e-89; M. ramanniana1e-653e-68; H. sapiens
    Diacylglycerol acyltransferase2.3.1.2000035.13e-58; B. napus2e-332e-51; D. melanogasterBest match
    Phospholipid acyltransferase2.3.1.-02416.10.0; P. anserinae-1373e-52; A. thaliana
    Sterol acyltransferase2.3.1.4304144.12e-69; S. pombe7e-56
    Sterol acyltransferase2.3.1.4303991.14e-65; S. kluyveri4e-79
    Serine palmitoyltransferase subunit 12.3.1.5006870.10.0; E. nidulans7e-854e-81; A. gambiae3e-83; A. thaliana
    Serine palmitoyltransferase subunit 22.3.1.5000447.10.0; E. nidulanse-157e-139; M. musculuse-131; S. tuberosom
Phospholipid synthesis
    Phosphatidylserine synthase2.7.8.801141.1e-107; S. cerevisiaeBest match7e-66; D. melanogaster
    Phosphatidylserine synthase2.7.8.802381.12e-76; T. aestivum4e-59Best match
    Phosphatidylserine decarboxylase4.1.1.6501004.1e-135; S. pombe3e-967e-72; A. thaliana
    Phosphatidylserine decarboxylase4.1.1.6503695.14e-94; S. cerevisiaeBest match3e-52; H. sapiens7e-54; A. thaliana
    Phosphatidylserine decarboxylase4.1.1.6502302.18e-67; B. fungorum3e-112e-21; A. thaliana
    Phosphatidylethanolamine methyl- transferase2.1.1.1708045.1e-168; S. pombee-102
    Phosphatidyl-N-methylethanolamine methyltransferase2.1.1.7104699.18e-48; S. cerevisiaeBest match3e-40; D. rerio
    Choline phosphotransferase2.7.8.203223.18e-38; S. pombe2e-321e-33; A. thaliana
    Diacylglycerol choline/ethanolamine transferase2.7.8.1/201993.15e-70; S. pombe3e-623e-45; B. napus
    CDP-alcohol transferase (probable cardiolipin synthase)2.7.8.-00135.12e-36; D. melanogaster8e-293e-29; M. musculus
    Phosphatidylinositol synthase2.7.8.1109192.11e-49; S. pombe2e-412e-42; R. norvegicus
    Choline kinase2.7.1.3203176.12e-58; S. pombe2e-465e-28; P. sativum
    Ethanolamine kinase2.7.1.8202726.12e-42; R. norvegicusBest match
    Cholinephosphate cytidylyltransferase2.7.7.1503880.16e-80; S. pombe1e-742e-59; P. sativum
    Phosphoethanolamine cytidylyltransferase2.7.7.1404289.11e-63; D. melanogaster3e-532e-60; R. norevgicus
    Inositol-3-phosphate synthase5.5.1.406666.1e-170; T. aestivume-291e-169; H. sapiensBest match
    Phosphatidylcholine/-inositol exchange protein (sec14)02263.1e-112; A. capsulatus3e-80
    Phosphatidylcholine/-inositol exchange protein (sec14)07320.17e-29; S. cerevisiaeBest match