TABLE 42.

Distribution and proposed role of transport-related small GTPasesa

Neurosporab proteinProposed transport roleS. cerevisiaeMammals
Rab proteins
    Minimal set required in all fungi
        NCU08477.1ER-GA, IGA, GA-ERYpt1pcRab1
        NCU06404.1LGA-PMSec4pcRab8
        NCU01532.1IGA, LGA-PM?Ypt31/32pcRab11
        NCU05234.1IGA, LGA-LE, LE-LGAYpt6pcRab6
        NCU03711.1LE-VYpt7pcRab7
        NCU00895.1, NCU06410.1PM-EE, EE-LEYpt51/52/53pcRab5
    Specific for S. cerevisiae or S. pombe
?Ypt10p
?Ypt11p
EE-LE, LE-VRab7
    Lost in S. cerevisiae, but present in S. pombe, filamentous fungi and animals
        NCU00889.1EE-PMRab4
    Present in filamentous fungi and animals, but not S. cerevisiae
        NCU01647.1ER-GA, GA-ERRab2
        NCU01453.1PM-EE?, EE-PM?Rab18?
        NCU08271.1 (unusually long protein)PM-EE, EE-LERab5
ARF/ARF-like proteins
    Minimal set required in all fungi
        NCU08340.1GA-ER, IGA, LGA, PMArf1/2pcArf1
        NCU08989.1LGAArl1pcArl1
        NCU00333.1LGAArl3pcArl3
        NCU00218.1?Arf3p (=Arl2p)cArl2
        NCU00381.1ER-GASar1pcSar1
    Present in filamentous fungi and animals, but not S. cerevisiae
        NCU07173.1PM-EEArf6
        NCU08618.1?Hypothetical protein
  • a Abbreviations: GA, Golgi apparatus; LGA, late Golgi apparatus; IGA, intra-Golgi transport; PM, plasma membrane; ER, endoplasmic reticulum; EE, early endosome; LE, late endosome; V, vacuole.

  • b Orthologues are also present in M. grisea and A. fumigatus.

  • c Orthologues are also present in S. pombe and C. albicans.