TABLE 60.

Neurospora proteins exhibiting similarities to human proteins associated with disease

EnzymeDisease or disorderNCU no.BLAST match
Best overallS. cerevisiaeS. pombeHuman
With homologues in yeast
    10 chloride channel proteinDent's disease (renal)06624.1S. pombe/e-124e-135e-162e-124
    DNA ligase I polydeoxyribonucleotide synthase [ATP]Immunodeficiency09706.10S. pombe, R. norvegicus DNL1/7e-614e-467e-613e-60
06481.1S. cerevisiae Cdc9/0.00.0e-116e-146
    Calcium/calmodulin-dependent protein kinase type I (CAM kinase 1)Cancer09212.1S. pombe Srk1/e-1338e-92e-1335e-57
09123.1E. nidulans KCC1/e-166e-962e-647e-69
    Probable ATP-dependent permease (multidrug resistance-associated protein 1)Cancer related09012.1S. cerevisiae YCFI/0.00.00.00.0
    Probable ATP-dependent permease (multidrug resistance-associated protein 2)Cancer related08358.1S. cerevisiae YBT1/0.00.0e-146e-180
    Copper-transporting ATPase (copper pump 2)Wilson's disease07531.1S. cerevisiae Pca1/0.00.07e-708e-66
08341.1A. thaliana RAN1/0.0e-1750.0e-170
    Carnitine acetyltransferaseCPT2 deficiency/metabolic08002.1S. cerevisiae Cat2/e-123e-123None6e-86
    TSC2Tuberous sclerosis type 24105.1S. pombe SPAC630.13c/e-100Nonee-100NP_066399.1; 3e-36
    COT1 kinaseMyotonic dystrophy07296.1S. cerevisiae Cbk1/e-151e-151e-1442e-67a
Without homologues in yeast
    Tripeptidyl-peptidase I precursor, TPP-I (CLN2)Ceroid-lipofuscinosis08656.1A. oryzae aorsin/7e-33NoneNone4e-18
08418.1A. oryzae tripeptidylpeptidase A/e-145NoneNone5e-59
04903.1C. brassiana tripeptidylpeptidase precursor/1e-89NoneNone5e-38
    Calpain-like thiol proteaseLimb girdle MD+ 2A-CAPN31151.1N. crassa NCU00251.1/e-120NoneNone5e-38
0251.1N. crassa NCU01151.1/e-110NoneNone9e-30
3355.1N. crassa NCU01151.1/8e-98NoneNone8e-37
  • a Also similar to human NDR kinase (e-108).