TABLE 5.

Neurospora homologues of proteins involved in histone modificationsa

ProteinLocus (gene)Match found by BLAST
Best matchdS. cerevisiaeS. pombeAnimalbPlantc
Histone acetyltransferases
    ScHat16472.1 (hat-1)S. cerevisiae4e-284e-144e-223e-15
    HsTAFII2502556.1 (hat-2)S. pombeNo match1e-1091e-493e-27
    ScElp31229.1 (elp-3)S. cerevisiae0.00.00.00.0
    ScGcn5No ID (ngf-1)Y. lipolytica; 1e-1381e-1351e-1167e-786e-79
    ScEsa15218.1 (hat-4)S. cerevisiae1e-1221e-1229e-962e-90
    ScSas22249.1 (hat-5)S. cerevisiae2e-341e-253e-342e-34
    ScSas34782.1 (hat-6)S. pombe7e-781e-952e-841e-79
Protein acetyltransferases
    SpArd1/ScNat31276.1S. pombe1e-262e-446e-401e-32
    ScMak32417.1P. anserina; 3e-751e-334e-356e-411e-33
    SpAts17589.1P. aeruginosa; 8e-25No match7e-222e-144e-20
    GNAT-type9914.1B. iaponicum; 2e-5No matchNo matchNo matchNo match
    GNAT-type4583.1B. cereus; 1e-13No matchNo matchNo matchNo match
Deacetylases
    ScHda1/SpClr31525.1 (hda-1)S. pombe1e-1371e-1454e-804e-67
    ScHos22795.1 (hda-2)A. nidulans; 1e-1431e-1041e-1061e-1002e-95
    ScRpd30824.1 (hda-3)A. nidulans; 1e-1781e-1611e-1441e-1461e-127
    ScHos37018.1 (hda-4)S. cerevisiae9e-83No hits3e-188e-25
    ScHst1/HsSirtuin14737.1 (nst-1)S. pombe6e-805e-887e-62No match
    ScHst2/HsSirtuin20523.1 (nst-2)S. pombe5e-567e-711e-65No match
    ScHst43059.1 (nst-3)S. pombe5e-614e-735e-21No match
    ScHst3/HsSirtuin34859.1 (nst-4)S. cerevisiae7e-283e-152e-60.001
    HsSirtuin40203.1 (nst-5)A. thalianaNo matchNo match5e-358e-42
    HsSirtuin55973.1 (nst-6)M. musculusNo matchNo match1e-35No match
    HsSirtuin77624.1 (nst-7)A. thalianaNo matchNo match3e-431e-49
Protein methyltransferases
    Lysine, SET domain
        SpClr44402.1 (dim-5)S. pombeNo match2e-437e-362e-26
        ScSet11206.1 (set-1)S. cerevisiae3e-642e-533e-537e-45
        ScSet20269.1 (set-2)S. pombe1e-1041e-1163e-503e-43
        DmAsh11932.1 (set-3)R. norvegicus1e-29 (set 2)3e-252e-372e-31
        ScSet3/Set44389.1 (set-4)H. sapiens9e-108e-89e-130.027
        HsG9a6119.1 (set-5)C. elegansNo matchNo match8e-12No match
        NcSET-69495.1 (set-6)S. pombe2e-67e-369e-63e-6
        DmEn(z)/AtMedea7496.1 (set-7)M. musculusNo matchNo match4e-291e-25
        NcSET-81973.1 (set-8)H. sapiens5e-4No match4e-134e-6
    Lysine, non-SET
        ScDot16266.1S. cerevisiae3e-38No match5e-22No match
    Arginine
        HsPRMT1/ScHmt17459.1 (prm-1)S. pombe1e-1111e-1161e-1003e-98
        HsPRMT31669.1 (prm-3)S. pombe4e-626e-866e-672e-62
        HsPRMT5/ScHs17/SpSkb11613.1 (pp-2)S. pombe4e-691e-1075e-863e-77
Kinases
    ScSnf14566.1F. oxysporum; 01e-1341e-1231e-1031e-103
    ScSnf41471.1K. lactis; 2e-944e-924e-887e-488e-24
    ScGal833937.1S. cerevisiae1e-275e-235e-192e-10
    ScIp11/HsAurora B0108.1S. pombe1e-641e-1021e-874e-80
    EnNim-A3187.1 (nim-1)E. nidulans; 1e-1726e-68 (Kin3)3e-66 (Fin1)8e-63 (Nek2)1e-36
Ubiquitylases
    ScRad69731.1 (mus-8)N. haematococca; 4e-752e-634e-643e-573e-53
ADP-Ribosylases
    PARP8852.1 (parp)A. thalianaNo matchNo match3e-603e-67
  • a Histone phosphatases and histone kinases are listed in Tables 48 and 56, respectively. Note: Based on sequence comparisons with fungal Snf1p homologues, the Snf1 locus is misannotated at the WICGR but correct at MNCDB (CAD70761).

  • b Caenorhabditis elegans, Drosophila melanogaster, Strongylocentrotus purpuratus, Xenopus laevis, Mus musculus, or Homo sapiens.

  • c Arabidopsis thaliana, Vicia faba, or Oryza sativa.

  • d Species listed as best matches are Podospora anserina, Aspergillus nidulans, Physarum polycephalum, Vicia faba, Sordaria macrospora, Fusarium oxysporum, Yarrowia lipolytica, Candida albicans, Nectria haematococca, and Hypocrea jecornia.