TABLE 2.

Selection of S. enterica serovar Typhimurium fitness factors

Fitness factorLocationaFunction
Type III effector proteins
    SipA,B,C,DChr. (SPI-1)SPI-1 TTSS effector + transport, actin manipulation
    SptPChr. (SPI-1)SPI-1 TTSS effector, tyrosine phosphatase, GAPb
    AvrAChr. (SPI-1)SPI-1 TTSS effector, NF-κB signaling
    SopBChr. (SPI-5)SPI-1 TTSS effector, inositol phosphate phosphatase
    SopAChr.SPI-1 TTSS effector, function unclear
    SlrPChr.SPI-1 TTSS effector, function unclear
    SopDChr.SPI-1 TTSS effector, function unclear
    SopESopEΦSPI-1 TTSS effector, exchange factor for Cdc42, Rac1
    SopE2Phage remn.SPI-1 TTSS effector, exchange factor for Cdc42
    SspH1GIFSY-3SPI-1/2 TTSS effector, NF-κB signaling
    SseA-GChr. (SPI-2)SPI-2 TTSS effectors and transport proteins
    SsaBChr. (SPI-2)SPI-2 TTSS effector, function unclear
    SseJChr.SPI-2 TTSS effector, function unclear
    SifAChr.SPI-2 TTSS effector, vesicle traffic
    SseIGIFSY-2SPI-2 TTSS effector, function unclear
    SspH2Phage remn.SPI-2 TTSS effector, function unclear
    SopD2Chr.SPI-2 TTSS effector, function unclear
    SifBChr.SPI-2 TTSS effector, function unclear
    GogBGIFSY-1Possible SPI-2 TTSS effector, function unclear
Others
    SpvBPlasmidADP ribosyltransferase for actin
    SodCIGIFSY-2Superoxide dismutase
    SodCIIChr.Superoxide dismutase
    SodCIIIFels-1Superoxide dismutase
    NanHFels-1Neuraminidase, role in virulence unclear
    FliCChr.Flagella, chemotaxis and inflammation
    PefAPlasmidPlasmid-encoded fimbriae, adhesion
    FimAChr.Type I fimbriae
    LpfAChr.Long polar fimbriae
    LPSChr./phageLipopolysaccharide, principal outer membrane component, protection, inflammation
  • a Chr., chromosome; remn, remnant.

  • b GAP, GTPase activating protein.