TABLE 3.

Putative and proven virulence genes in S. pyogenes MGAS315a

Fitness factorOpen reading frame no.b
Proteinase
    C3 degrading proteinase1598
    Exfoliative toxin-like protein0632
    IdeS/Sib380583
    Streptokinase A1698
    C5a peptidase1726
    SpeB/Cysteine proteinase1742
    Serine proteinase1864
Adhesin
    GRAB1032
    SclA1702-3
    SclB0738
    M protein1727
    Fibronectin-binding protein F2-like0104
    Internalin-like protein1035
    Laminin-binding protein1725
Hemolysinc
    SLO0130
    SLS0488
    CAMP0905
    Hemolysin (hylA1)1153
    Hemolysin homolog (hylX)0276
    Hemolysin homolog (hylIII)0815
Capsule synthesis and degradation
    Hyalunonate synthase (hasA)1851
    Hyaluronidase1294
    Hyaluronidase1101, 1214, 1418
DNase
    Mitogenic factor (mf)1745
    Mitogenic factor-like1095
    Sda1409
Superantigen
    SpeA1301
    SpeG0155
    SpeK1205
    SpeL1205
    SSA0920
Immunoreactive antigen
    Immunogenic secreted protein1562
    Myosin crossreactive antigen0332
    Immunogenic secreted protein1731
Regulators
    SpeB protease transcription regulator (rgg)1744
    RopA (trigger factor)1634
    M protein transacting positive regulator1728
    CsrR/S (CovR/S)0244-5
    RofA0157
Bacteriocin
    Salivaricin precursor1652
    SalK homolog1646
  • a Modified from reference 164 with permission.

  • b Phage-encoded genes are in bold.

  • c SLO, streptolysin; SLS, streptolysin S; CAMP, CAMP factor.