TABLE 4.

Putative and proven fitness factors identified in S. aureus N315a

ProductOpen reading frameGene name
Exoenzymes
    Phosphatidylinositol phosphodiesteraseSA0091 plc
    StaphylocoagulaseSA0222 coa
    LipaseSA0309 geh
    NucleaseSA0746
    Cysteine proteaseSA0900 sspB
    V8 proteaseSA0901 sspA
    ThermonucleaseSA1160 nuc
    Serine protease SA1627-31 splA-F splF
    Staphylokinase SA1758 sak
    HyaluronidaseSA2003 hysA
    Zinc metalloproteinase aureolysinSA2430 aur
    Triacylglycerol lipaseSA2463 lip
Toxins
    Probable exotoxins SA0382-93 set6-set14
    Alpha-hemolysinSA1007
    Leukotoxins SA1637, SA1638 lukD, lukE
    Enterotoxins SA1642-48 seg, sen, ent2, ent1, sei, sem, seo
    Enterotoxin P SA1761 sep
    Enterotoxin A SAV119 sea
    Leukocidin LukM ?SA1813
    Enterotoxins SA1816, SA1817 sel, sec3
    Toxic shock syndrome toxin 1 SA1819 tst
    Delta-hemolysinSAS065 hld
    Gamma-hemolysin componentsSA2207-9 hlgA, hlgC, hlgB
Adhesins
    Fibrinogen-binding proteinsSA0742-3 clfA,B
    SA0519-21 sdrC-sdrE
    Extracellular matrix-binding proteinsSA1267, SA1268 ebhA, ebhB
    Elastin-binding proteinSA1312 ebpS
    Fibronectin-binding proteinsSA2290, SA2291 fnbB, fnbA
    Intercellular adhesion proteinsSA2459-62 icaA-icaD
Othersc
    MHC class II-like proteinSA0102
    IgG-binding protein ASA0107 spa
    IgG-binding protein SBISA2206 sbi
  • a Modified from reference 132 with permission.

  • b Genes located on pathogenicity islands are in bold; those on prophages are in bold and italics.

  • c IgG, immunoglobulin G.