TABLE 4.

Putative and proven fitness factors identified in S. aureus N315a

ProductOpen reading frameGene name
Exoenzymes
    Phosphatidylinositol phosphodiesteraseSA0091plc
    StaphylocoagulaseSA0222coa
    LipaseSA0309geh
    NucleaseSA0746
    Cysteine proteaseSA0900sspB
    V8 proteaseSA0901sspA
    ThermonucleaseSA1160nuc
    Serine proteaseSA1627-31splA-F splF
    StaphylokinaseSA1758sak
    HyaluronidaseSA2003hysA
    Zinc metalloproteinase aureolysinSA2430aur
    Triacylglycerol lipaseSA2463lip
Toxins
    Probable exotoxinsSA0382-93set6-set14
    Alpha-hemolysinSA1007
    LeukotoxinsSA1637, SA1638lukD, lukE
    EnterotoxinsSA1642-48seg, sen, ent2, ent1, sei, sem, seo
    Enterotoxin PSA1761sep
    Enterotoxin ASAV119sea
    Leukocidin LukM ?SA1813
    EnterotoxinsSA1816, SA1817sel, sec3
    Toxic shock syndrome toxin 1SA1819tst
    Delta-hemolysinSAS065hld
    Gamma-hemolysin componentsSA2207-9hlgA, hlgC, hlgB
Adhesins
    Fibrinogen-binding proteinsSA0742-3clfA,B
    SA0519-21sdrC-sdrE
    Extracellular matrix-binding proteinsSA1267, SA1268ebhA, ebhB
    Elastin-binding proteinSA1312ebpS
    Fibronectin-binding proteinsSA2290, SA2291fnbB, fnbA
    Intercellular adhesion proteinsSA2459-62icaA-icaD
Othersc
    MHC class II-like proteinSA0102
    IgG-binding protein ASA0107spa
    IgG-binding protein SBISA2206sbi
  • a Modified from reference 132 with permission.

  • b Genes located on pathogenicity islands are in bold; those on prophages are in bold and italics.

  • c IgG, immunoglobulin G.