TABLE 1.

Downstream targets of mTOR

TargetRelated functionPhosphorylation by:Phosphorylation site(s)Consequences of regulation by mTORReference(s)
mTOR pathway presentmTOR, direct or indirect
CLIP-170Cytoskeleton organization+NDaNDActivation 44, 45
eEF2 kinaseProtein kinase+IndirectNDInhibition 193
Glycogen synthaseGlycogen synthesisNDNDNDActivation 11, 218
HIF-1αTranscriptionNDNDNDActivation 115, 237
lipinAdipose tissue development+NDNDActivation 116
4EBP-1Translation inhibitor+DirectT37, T46, S65, T70Inhibition 85, 148
PKCδProtein kinase+NDS662Activation 176
PKCεProtein kinase+NDS729Activation 176
IRS-1Adaptor protein+NDS302Inhibition 99, 100, 228
PP2APhosphatase+DirectNDInhibition 17, 183
p21 CDKIProtein kinaseNDNDNDInhibition 114
p27 CDKIProtein kinaseNDNDNDInhibition 114, 117
S6K-1Protein kinase+DirectS371, T389Activation 48, 190
RbTranscription factor+NDS780, S795, S807, S811Inhibition 241
STAT3Transcription factor+DirectS727Activation 263
URIComponent of transcriptional complex+NDNDActivation 90
TIF-IAComponent of transcriptional complex+IndirectS44Activation 159
S199Inhibition
  • a ND, not determined.