Sugar substrates transported by various PTS permeasesa

Family (TC no.)bSubfamily (TC no.)bSubstrates
Glc (4.A.1)Glucose (4.A.1.1)Glucose, N-acetylglucosamine, maltose, glucosamine, andα -glucosides
Glucoside (4.A.1.2)β-Glucosides, sucrose, trehalose, and N-acetylmuramic acid
Fru (4.A.2)Fructose, mannitol, mannose, and 2-O-α-mannosyl d-glycerate
Lac (4.A.3)Lactose (4.A.3.1)Lactose, aromatic β-glucosides, and cellobiose
N,N′-diacetylchitobiose (4.A.3.2) N,N′-Diacetylchitobiose and lichenan oligosaccharides
Gut (4.A.4)Glucitol (sorbitol) and 2-methyl-d-erythritol
Gat (4.A.5)Galactitol and d-arabitol
Man (4.A.6)Glucose, mannose, sorbose, fructose, glucosamine, galactosamine, N-acetylgalactosamine, and several other sugars; broad-specificity porters
Asc (4.A.7) l-Ascorbate (anaerobic utilization)
  • a Sugars transported by functionally characterized members of the seven PTS permease families are indicated.

  • b The transporter classification number (TC no.) for each of the PTS families and subfamilies is provided. For more information, refer to