TABLE 13.

PTS proteins with extra non-PTS domainsa

CategoryProteinProtein size (aa)Length of X (aa)Homology of XOrganismGI no.
AIIAFru-X-FPr-FPr499150Unknown Haemophilus influenzae Rd KW2016272396
IIAFru-X-FPr-FPr502150Unknown Mannheimia succiniciproducens MBEL55E52426235
BIIAFru-X271120Unknown Chlorobium tepidum TLS21673462
IIANtr-X311150CBS domain Fusobacterium nucleatum subsp. nucleatum ATCC 2558619705231
IIABCGlc-X841170MAD, Smc Mesoplasma florum L150364823
IIABCGlc-X858180Sbc Mesoplasma florum L150364848
IIABCGlc-X874170HEC1 Mesoplasma florum L150365435
IIABCGlc-X849200Zn ribbon Mesoplasma florum L150365128
IIABCGlc-X854200Smc Mesoplasma florum L150365134
IIABCGlc-X1,020280Smc Mycoplasma penetrans HF-226553906
IIBCGlc-X628130TOPEUc, Smc Mycoplasma mycoides subsp. mycoides SC strain PG142561174
IIBCFru-X61380Unknown Mycoplasma mycoides subsp. mycoides SC strain PG142561366
IICAsc-X660135Unknown Mycoplasma pneumoniae M12913508235
CX-IIANtr22580HTH motif Chlamydia trachomatis D/UW-3/CX15605011
X-IIANtr22675HTH motif Chlamydophila caviae GPIC29840113
X-IIANtr22575HTH motif Chlamydophila pneumoniae AR3916752983
X-IIANtr23990HTH motif Parachlamydia sp. strain UWE2546445900
X-IIANtr23590HTH motif Pirellula sp. strain 132473906
X-IIANtr22575Unknown Geobacter sulfurreducens PCA39995841
X-IIANtr20160Unknown Treponema denticola ATCC 3540542526589
X-IIAGat21555Unknown Lactobacillus johnsonii NCC 53342518211
X-IIBFru414320Unknown Mycoplasma gallisepticum R31544567
X-IIBCFru564110Unknown Mannheimia succiniciproducens MBEL55E52426233
DX-IICGlc492165Unknown Salmonella enterica subsp. enterica serovar Typhi Ty229144387
X-IIC2Gut23050Unknown Mesorhizobium loti MAFF30309913473118
EX-IICFru-X629N-100, C-150Unknown, unknown Mycoplasma mycoides subsp. mycoides SC strain PG142560835
X-ΔIIBAsc17880Unknown Salmonella enterica subsp. enterica serovar Typhi Ty229144680
ΔIIBGlc-X8740Unknown Lactobacillus johnsonii NCC 53342519701
FIICLac-X704250DUF2 Vibrio cholerae O1 bv. eltor strain N1696115641224
IICLac-X698250DUF2 Vibrio vulnificus CMCP627366325
IICLac-X655250DUF2 Vibrio vulnificus CMCP627367219
IICLac-X681250DUF2 Vibrio parahaemolyticus RIMD 221063328901284
IICLac-X704250DUF2 Wolinella succinogenes DSM 174034557244
GX-IIAFru589415Na+/H+ antiporter Pirellula sp. strain 132474980
X-IIAFru701550Na+/H+ antiporter Borrelia garinii PBi51598702
X-IIAFru701550Na+/H+ antiporter Borrelia burgdorferi B3115594792
X-IIAGlc648500Na+/melibiose symporter Lactobacillus plantarum WCFS128379785
X-IIAGlc652500Na+/melibiose symporter Lactobacillus plantarum WCFS128379802
X-IIAGlc653500Na+/melibiose symporter Lactobacillus johnsonii NCC 53342518347
X-IIAGlc654500Na+/melibiose symporter Lactobacillus johnsonii NCC 53342518782
X-IIBGlc349265TIM Pasteurella multocida Pm7015603505
X-X-IIAFru967N-475, 350PspF, COG3933 Thermoanaerobacter tengcongensis 20806706
  • a Proteins were grouped for convenience based on (i) whether the non-PTS domains were partial domains (categories A to E) or full-length domains (categories Fand G) and (ii) whether the non-PTS domain was in the middle (category A), at the C terminus (categories B and F), or at the N terminus (categories C to E) of the protein. While category C includes proteins with non-PTS domains fused N-terminally to PTS enzyme IIA or IIB, category D includes N-terminal fusions of non-PTS domains to the PTS enzyme IIC; category E is a miscellaneous group of fusion proteins.