TABLE 1.

Structural complexity of PTS

Protein or processDescription
IICPermease and receptor (sugar specific)
IIBDirect phosphoryl donor (permease specific)
IIAIndirect phosphoryl donor (family specific)
IIDMannose family-specific auxiliary protein (essential but of unknown biochemical function)
EI and HPrGeneral energy-coupling proteins (PTS pathway specific)
EnolaseUpstream energy-yielding enzyme (PEP generating)
PhosphoglucoisomeraseDownstream substrate-converting enzyme
GlycolysisInterconnecting cyclic pathway
PTS + glycolysisMetabolite-induced metabolon