TABLE 1.

Staphylococcus aureus cell wall-anchored surface proteins

Surface proteinaaaLigand(s)bMotifcSortasedReference(s)
Protein A (Spa)508Immunoglobulin, von Willebrand Factor, TNFReLPETGA 64, 70, 206
Fibronectin binding protein A (FnbpA)1,018Fibronectin, fibrinogen, elastinLPETGA 178
Fibronectin binding protein B (FnbpB)914Fibronectin, fibrinogen, elastinLPETGA 89
Clumping factor A (ClfA)933FibrinogenLPDTGA 124
Clumping factor B (ClfB)913Fibrinogen, keratinLPETGA 141
Collagen adhesion (Cna)1,183CollagenLPKTGA 152
SdrC947UnknownLPETGA 90
SdrD1,315UnknownLPETGA 90, 91
SdrE1,166UnknownLPETGA 90
Pls1,637UnknownLPDTGA 122, 123
SasA2,261UnknownLPDTGA 122, 123
SasB937UnknownLPDTGA 122, 123
SasC2,186UnknownLPNTGA 122, 123
SasD241UnknownLPAAGA 122, 123
SasE/IsdA354HemeLPKTGA 121-123
SasF637UnknownLPKAGA 122, 123
SasG/Aap1,117UnknownLPKTGA 78, 122, 123
SasH308UnknownLPKTGA 122, 123
SasI/HarA/IsdH895HaptoglobinLPKTGA 42, 121-123
SasJ/IsdB645Hemoglobin, hemeLPQTGA 121-123
SasK211UnknownLPKTGA 122, 123
IsdC227HemeNPQTNB 110, 121
  • a aa, protein length in amino acids.

  • b Molecular component(s) recognized and bound by protein.

  • c Consensus motif recognized by sortase and present in C-terminal cell wall sorting signal.

  • d Sortase for which cell wall surface protein is substrate.

  • e TNFR, tumor necrosis factor receptor.