TABLE 3.

Postulated nuclear poly-ADP-ribose-associated proteins in vivo

Substrate(s)Proposed functional relevanceReference(s)
Histones H1 (H1.1, H1.2, H1.3, H1.4, H1.5), H2A, H2B, H3, H3.1, H4Inhibition of DNA binding activity129, 213, 322, 324, 367
High-mobility-group proteins HMGA1a, HMGA1b, HMGA2, HMGB1, HMGB2, HMGN1, HMGN2NAa117, 135, 324, 325
Low-mobility-group proteinNA117
Poly-ADP-ribose polymerases PARP-1, PARP-1b, PARP-2, PARP-3, PARP-4, PARP-5, PARP-6a, PARP-6bInhibition of DNA binding activity?20
Topoisomerase I, topoisomerase IIInhibition of catalytic activity121, 190, 355, 372
A24 proteinNA213, 322, 368
Heterogeneous ribonucleoproteins hnRNP A1, hnRNP A2/B1, hnRNP C1/C2, hnRNP G, hnRNP H, hnRNP K, hnRNP MNA129
Lamin A/CNA3, 377
Numatrin/B23NA226
Nucleolin/C23NA226
Centromere-binding proteins CENPA, CENPB, Bub3NA349
MARCKS F52/MacMARCKS/MRP50/GAP-43NA69, 352
p53Inhibition of DNA binding249, 321, 372
DNA polymerase alphaInhibition of catalytic activity114, 364
PCNAInhibition114, 364
Telomeric repeat binding factor-1Inhibition of DNA binding376
CTCFEnhancement of DNA binding454
NuMANA68
  • a NA, not analyzed.