TABLE 2.

Nuclear substrates for covalent mono-ADP-ribosylation

Substrate(s)Amino acid modification sitesFunctional relevanceReferences
Histone H1 (H1.1, H1.2, H1.3, H1.4, H1.5)Glutamic acid residues E2 (all), E15 (all), E114 (H1.2), E115 (H1.3/H1.4), E117 (H1.5); arginine residue R33 (H1.3); phosphoserine residues(?)NAa293, 308, 335, 373, 389, 416
Histone H2AGlutamic acid residues, arginine residues, phosphoserine residues (?)NA141, 308, 373, 389
Histone H2BGlutamic acid residue E2, arginine residues, phosphoserine residues (?)NA55, 292, 308, 373, 389
Histone H3Arginine residues, phosphoserine p-S57 (?)NA141, 308, 373, 389
Histone H4Arginine residues, phosphoserine residues (?)NA141, 308, 373, 389
High-mobility-group proteins HMGA1a, HMGA1b, HMGA2, MGB1, HMGB2, HMGN1, HMGN2Arginine and glutamic acid residues (?)NA117, 148, 394-396, 405
Low-mobility-group proteins (?)
  • a NA, not analyzed.