TABLE 1.

Major morphopathogenic determinants in C. albicans

C. albicans proteinS. cerevisiae homologaProtein functionReference(s)
Gpa2Gpa2α subunit of G protein 193, 249
Gpr1Gpr1G protein receptor 193, 249
Ras1Ras2GTPase 92
Cdc25Cdc25Ras-GEF 112, 193
Cdc35/Cyr1Cyr1Adenylate cyclase 139, 243
Srv2Cap1Adenylate cyclase-associated protein 13
Pde2Pde2High-affinity phosphodiesterase 16, 143
Flo8Flo8Transcription factor 56
Tpk1/Tpk2Tpk1/Tpk2Catalytic subunit of cAMP-dependent PKA 37, 66, 276
Bcy1Bcy1Regulatory subunit of cAMP-dependent PKA 58
Cst20Ste20PAK 153, 171
Hst7Ste7MAPKK 171, 266
Cek1Fus3/Kss1MAPK 69
Cpp1Cpp1MAPK phosphatase 114, 256
Tec1Tec1Transcription factor of TEA/ATTS family 257
Cph1Ste12Transcription factor 181, 195
Efg1Sok2/Phd1Transcription factor of HLH family 36, 175, 285, 294
Cph2Hms1Transcription factor of HLH family 169, 170
Fkh2Fkh2Forkhead transcription factor 29
Mcm1Mcm1Transcription factor of MADS box family 245
Cdc42Cdc42Rho G protein 119, 305
Cln2Cln2G1 cyclin 185
Tup1Tup1Transcriptional repressor 41, 210
Nrg1Nrg1Transcription factor with zinc finger domain 43, 210, 211
Mig1Mig1Transcription factor with zinc finger domain 210
Rfg1Rox1DNA-binding partner of Tup1 146, 148
Rbf1Rbf1RPG box-binding factor 137, 262
Rap1Rap1Transcriptional silencer 34
Rad6Rad6Transcription-repressing factor 176
Hog1Hog1MAPK for oxidative stress 2, 3, 227
Ssn6Ssn6Forms complex with Tup1 136
Sln1Sln1Histidine kinases 212
Hxk1No known homologGlcNAc kinase 162, 267, 326
Hwp1No known homologHyphal wall protein 262, 283, 303
Int1Int1Surface glycoprotein 7, 25, 98
Als1Als1Adhesin factor 95, 329
Sap1 to Sap9No known homologAspartyl proteinases 134, 165, 255
Plb1Plb1Phospholipase 173, 208
Gcn4Gcn4General amino acid control 302
Gcn2Gcn2General amino acid control 301
Gap1Gap1General amino acid permease 35
Csy1Csy1Amino acid sensor 45
Rim20PalA*Proteolysis of Rim101 72, 73
Rim8PalF*Proteolysis of Rim101 72, 73
Rim101PacC*Zinc finger transcription factor 72, 73, 87, 166
Czf1No known homologPutative zinc finger transcription factor 111
Hgc1Cln21G1 cyclin-related protein 332
Sho1Sho1Adaptor protein 244
Crz1Crz1Calcineurin-regulated transcription factor 250
Mkc1Mkc1Mitogen-activated protein kinase 80
Rsr1Rsr1Ras-like GTPase 118
Bud2Bud2GTPase-activating protein 118
Cln3Cln3G1 cyclin 59
Clb2, Clb4Clb2, Clb4B-type cyclin 28
Erg1Erg1Epoxidase 232
Mep1, Mep2Mep1, Mep2Ammonium permease 33
Cdc4Cdc4Ubiquitin ligase 8
Pmt4Pmt4Mannosyltransferase 236
Hsl1Hsl1Ser/Thr protein kinase 304
Pld1Pld1Phospholipase D1 82
Ecm33Ecm33GPI-anchored protein 199
  • a *, A. niger protein.