The MPER of gp41 is critical for HIV-1 infection

The region is very conserved162, 189, 199, 273
Important contribution to the activity of the viral inhibitor T-20113, 123
Epitopes of bNt MAbs 2F5, 4E10, and Z13 are located in this region162, 273
Deletion or substitution of sequence within this region affects fusion13, 159, 186, 199, 271
Peptides from this region associate with lipid membrane and cause membrane leakage157, 220, 221
Possible involvement in gp41 oligomerization and location in the membrane196
Binding of MPER to galactosyl ceramide is important for mucosal infection mediated by transcytosis4, 5, 259