TABLE 3.

Divisome proteins encoded in different bacterial genomes

DivisomeaFunctionHomologueb in:
E. coliB. subtilisS. coelicolorM. tuberculosis
FtsAPositive regulator of FtsZ assembly, membrane associated, actin like++
FtsBBridge cytoplasmic with periplasmic, transmembrane, forms tripartite complex with FtsL and FtsQ+DivICDivIC?
FtsEUnknown, ABC transporter family+++
FtsISynthesize septal PG, transpeptidase (PBP 3)++++
FtsKDNA partitioning, large multifunctional membrane protein+SpoIIIE++
FtsLBridge cytoplasmic with periplasmic, transmembrane, forms tripartite complex with FtsB and FtsQ+++
FtsNUnknown, weak homology to amidase, binds PG+
FtsQBridge cytoplasmic with periplasmic, many protein-protein interactions, transmembrane+DivIB++
FtsWPredicted transporter of PG precursors, multitransmembrane protein+++Interacts with FtsZ and FtsI and may substitute for lack of ZipA or FtsA
FtsXUnknown, ABC transporter family+?+
FtsZInitiates Z ring, helps constrict ring, tubulin like, GTPase++++
ZipAPositive regulator of FtsZ assembly, membrane associated+ZapA
AmiCSeparates daughter cells by hydrolyzing septal PG, amidase+???
EnvCSeparates daughter cells by hydrolyzing septal PG, hydrolase+???
  • a FtsH, FtsJ, and FtsY are not involved in cell division (FtsY has pleitropic effects on cell division).

  • b +, present in genome; −, not found in genome; ?, other homologues may exist.