TABLE 4.

Inhibitors of FtsZ assembly

InhibitorFunctionHomologuea in:
E. coliB. subtilisS. coelicolorM. tuberculosis
EzrANegative regulator of FtsZ assembly, topology similar to that of ZapA?+?
MinCNegative regulator of FtsZ assembly at poles, binds and oscillates between poles with MinD++
MinDOscillates MinC from pole to pole, ATPase, binds to membrane until MinE stimulates ATP hydrolysis++
MinESweeps MinCD complex from one pole to the other, stimulates MinD ATPase and release of MinCD from membrane+DivIVA; rather than oscillating between poles, remains at poles, tethering MinCD complexDivIVADivIVA orthologue, Ag84, encoded by wag31
SulANegative regulator of FtsZ assembly, induced by SOS response+YneA, structurally unrelated to SulA but functionally similar?
SepFUnknown, interacts with FtsZ and localization depends on FtsZ?+??
SlmANegative regulator of FtsZ assembly, prevents septum assembly over nucleoid (nucleoid occlusion)+??
NocNegative regulator of FtsZ assembly, prevents septum assembly over nucleoid (nucleoid occlusion)?+??
CrgANegative regulator of FtsZ assembly++ (Rv0011c)
  • a +, present in genome; −, not found in genome; ?, other homologues may exist.