TABLE 5.

Effect of ALS gene deletion on adherence to various ligands and cellsa

GeneAdherence to indicated host cell or ligandAggregationGrowthBiofilmReference(s)
HUVECFaDuBECRHEFibronectinLaminin
ALS1 NC, ↓NC, ↓NCNCNCNCSmall cell size, delayed filamentation 1, 113, 144, 273, 300, 413, 414
ALS2 NTNCNCNCNCReduced hyphal formation 414, 416
ALS3 NC, ↓NCNCNCNC↓ in vitro; NC in vivo 144, 273, 282, 300, 412-414
ALS4 NTNCNCNTNTNCReduced hyphal formation on RPMINC 414, 416
ALS5 NTNCNTDecreased growth rateNT 414
ALS6 NTNCNTNTDecreased growth rateNT 414
ALS7 NTNCNTNTNCNCNT 414
ALS9 NTNCNCNTNCNTNCNC 414, 415
  • a All comparisons were made between strains with deletion of the indicated gene and the wild-type strain. Symbols and abbreviations: ↓, decreased adherence; ⇓, almost eliminated; ↑, increased adherence; NC, no change in adherence; NT, not tested. If different observations for the same strain were made in different reports, then two symbols are given.