TABLE 1.

Genes encoding catalytic subunits of eukaryotic DNA translesion polymerases

PolymeraseGene in:
S. cerevisiaeS. pombeD. melanogasterMouseHuman
Pol ζ REV3 rev3+ mus205/dmREV3 Rev3 REV3L
Rev1 REV1 rev1 + rev1 Rev1 REV1
Pol κ dinB +/mug40+ Polκ/DinB1 DINB1
Pol η RAD30 eso1 + a DNApol Polη RAD30A/XPV
Pol ι DNApol Polι RAD30B
  • a S. pombe eso1 + contains two separable protein domains. The amino-terminal end is homologous to Pol η and exhibits in vivo phenotypes and in vitro activities similar to those of Pol η homologs in other organisms (152, 241). The carboxy-terminal end is comprised of an essential sister chromatid cohesion protein (152).