TABLE 5.

Francisella subunit vaccine candidates

AntigenAdjuvantDose, μg (route)aChallenge strainBoostChallenge route (dose, CFU)bHost mouse strainProtectionReference
Ethanol-inactivated LVSFreund's adjuvant20 (i.p.)Schu S4Noi.n. (40)C3H/HeNYes94
LPSFreund's adjuvant20 (i.p.)Schu S4Noi.n. (40)C3H/HeNNo94
Outer membrane proteinsFreund's adjuvant20 (i.p.)Schu S4Noi.n. (40)C3H/HeNYes94
LPSFreund's adjuvant50 (s.c.)LVSYesi.p. (2.5 × 106)BALB/cYes73
OMPFreund's adjuvant100LVSYesi.p. (2.5 × 106)BALB/cYes73
LPSBovine serum albumin20 (s.c.)Type B no. 108Noi.d. (80)BALB/cYes42
Aerosol (30)BALB/cNo42
Type A no. 33Noi.d. (60)BALB/cNo42
Aerosol (50)BALB/cNo42
  • a i.p., intraperitoneal; s.c., subcutaneous.

  • b i.d., intradermal; i.n., intranasal.