TABLE 1.

Characteristics of Francisella speciesa

Species or subspeciesLD50 (CFU) in:StraindAccession no.Length (bp)No. of:
MicebHumanscGenesPseudogenese
F. tularensis subsp. tularensis<10<10Schu S4NC 0065701,892,8191,852201
FSC198NC 0082451,892,6161,852199
WY96-3418NC 0092571,898,4761,8720
F. tularensis subsp. holarctica<10<103LVSNC 0078801,895,9942,020213
OSU18NC 0083691,895,7271,932328
FTNF002-00NC 0097491,890,9091,8872
F. tularensis subsp. mediasiaticaNRfNRFSC147NC 0106771,893,8861,750297
F. novicida<10>103U112NC 0086011,910,0311,78114
  • a Adapted from Table 1 in reference 140 with kind permission from Springer Science + Business Media (© Springer 2005) and from reference 203 with kind permission of Wiley-Blackwell.

  • b Doses delivered subcutaneously.

  • c Estimated LD based on virulence in animal models and case studies.

  • d Several additional Francisella isolates are currently being sequenced, including F. tularensis subsp. tularensis (strains MA00-2987 [NZ ABRI00000000] and FSC033 [NZ AAYE00000000]), F. tularensis subsp. holarctica (strains FSC200 [NZ AASP00000000], FSC022 [NZ AAYD00000000], and 257 [NZ AAUD00000000], and F. novicida (strains FTG [NZ ABXZ00000000], FTE [NZABSS00000000], GA99-3548 [NZ ABAH00000000], and GA99-3549 [NZ AAYF00000000]).

  • e Refers to sequences resembling functional genes but thought to have lost protein-coding capability.

  • f NR, doses have not been reported.