TABLE 7.

Expression of Francisella antigens in heterologous hosts

F. tularensis antigen(s)HostAttenuating mutation(s)Vaccination routea (dose, CFU)Challenge strainBoostChallenge routeb (dose, CFU)Host mouse strainProtectionReference
IglCL. monocytogenesΔactAi.d. (106-107)LVSYesi.n. (4,400)BALB/cYes97
Schu S4YesAerosol (1 [10 LD50])BALB/cYes97
KatGL. monocytogenesΔactAi.d. (106-107)LVSYesi.n. (4,400)BALB/cNo97
Schu S4YesAerosol (1 [10 LD50])BALB/cNo97
AcpA, Bfr, DnaK, GroEL, PldL. monocytogenesΔactAi.d. (106-107)LVSYesi.n. (4,400)BALB/cNo97
Tul4S. enterica serovar TyphimuriumΔasd, Δcya, Δcrpi.p. (5 × 103)LVSNoi.v. (160-230)BALB/cJNo186
FopAS. enterica serovar TyphimuriumΔaroAi.v. (1 × 107)LVSYesi.p. (101-2.5 × 106)BALB/cNo73
  • a i.d., intradermal; i.p., intraperitoneal; i.v., intravenous.

  • b i.n., intranasal.