Table 1

Interactions between signaling systems in P. aeruginosa

ProteinTarget systemEffectMechanismReference(s)
LasRc-di-GMPActivationLasR binding to tbpA promoter192
PQSActivationBinding to pqsR promoter202
PqsEPYOActivationUnknown52, 71
RhlRPQSRepressionBinding to pqsR promoter202
RsaLPYORepressionDirect mechanism (binding to the phzA1 and phzM promoters) and indirect mechanism (binding to the promoter of LasI and inhibiting its transcription)42, 163, 165
RsmALasI, RhlIRepressionBinding to lasI and rhlI promoters105, 160, 168