Table 2

Endoplasmic reticulum chaperones

ClassProteinFunction(s)
Hsp100None
Hsp90None
    Hsp90 cochaperoneNone
Hsp70
    GRP170Lhs1Kar2 nucleotide exchange, substrate binding
    Hsp110None
    Hsp70Kar2Protein folding, translocation, UPR regulation, karyogamy
    Hsp70 NEFSil1Kar2 nucleotide exchange
Hsp40/J proteinSec63Kar2 ATPase activator, translocation, ER membrane
Scj1Kar2 ATPase activator
Jem1Kar2 ATPase activator, karyogamy, ER membrane
ChaperoninNone
    Chaperonin cochaperoneNone
sHSPNone
Other
    CalnexinCne1Folding of glycosylated proteins
    Protein disulfide isomerasePdi1Protein folding, disulfide redox chemistry
Mpd1Protein folding, disulfide redox chemistry
Mpd2Protein folding, disulfide redox chemistry
Eug1Protein folding, disulfide redox chemistry?
Eps1Protein folding, disulfide redox chemistry?, ER membrane