Table 2

Predicted SARPs encoded in the genome of S. coelicolor

SCO no.Length (aa)Domain(s)aFunctionbSpecies with orthologuec
5085255SARPActII-ORF4 (UCSR for actinorhodin)
6288276SARPCSR in Cpk cluster
41161,113SARP, ATPase, X?S. avermitilis, S. venezuelae
22591,334SARP, Y, ATPase, X?S. avermitilis, S. clavuligerus, S. griseus, S. scabiei, S. venezuelae
4426993SARP, NB-ARC, TPRAfsR (global regulator of antibiotic biosynthesis)S. avermitilis, S. clavuligerus, S. griseus, S. scabiei, S. venezuelae
6280543SARP, ZKasO (= CpkO) (UCSR for CPK)
5877265dSARPRedD (UCSR for RED)
3217638SARP, NB-ARCCdaR (UCSR for CDA)
0898660SARP, W?S. avermitilis, S. clavuligerus, S. griseus
  • a Domains are abbreviated as follows: SARP, Streptomyces antibiotic regulatory protein; NB-ARC, pfam00931, signaling motif shared by plant resistance gene products and regulators of cell death in animals; TPR, tetratricopeptide domain; W, X, Y, and Z, domains of unknown function.

  • b UCSR, ultimate cluster-situated regulators” (CSRs that directly activate biosynthetic genes).

  • c Orthologues were determined as reciprocal best hits in BLASTP analysis. These genomes are presented in annotated form at http://strepdb.streptomyces.org.uk.

  • d An alternative translational start to that usually allocated has been chosen, to take account of the known transcription start site.