Table 2

TFRs of known function

TFROrganismDescriptionaKnown ligand(s)PDB IDReference(s)
AbyCVerrucosispora maris AB-18-032Located in the abyssomicin biosynthesis cluster; predicted to regulate abyD encoding a MFS export pump; mutation decreases abyssomicin synthesis214
AcmG5Streptomyces iakyrusLocated in the actinomycin G biosynthesis cluster215
AcmPStreptomyces chrysomallus ATCC 11523Located in the actinomycin D biosynthesis cluster94
AcmUStreptomyces chrysomallus ATCC 11523Located in the actinomycin D biosynthesis cluster94
AcnRCorynebacterium glutamicumRegulates the aconitase (acn) gene4AC6, 4ACI, 4AF5145
AcrREscherichia coliRegulator of the AcrAB multidrug efflux pumpRhodamine 6G, ethidium, proflavine3BCG, 3LHQ, 2QOP112, 116
AcrR-likeEscherichia coli, Streptococcus uberisPutative regulator of rdmC and mph(B) genes involved in spiramycin and tylosin resistance103, 216
ActR (SCO5082)Streptomyces coelicolorLocated in the actinorhodin biosynthesis cluster; regulates expression of the ActA and ActB efflux pumpsActinorhodin, (S)-DNPA2OPT, 3B6C, 3B6A79
AcuRAlcaligenes faecalisPutative repressor for genes involved in dimethylsulfoniopropionate and acrylate catabolism217
AcuRRhodobacter sphaeroidesRegulates expression of AcuI and DddL involved in dimethylsulfoniopropionate and acrylate catabolismAcrylate218
AdeNAcinetobacter baumanniiRegulator of the AdeIJK efflux pump219
AefRPseudomonas syringaeRegulates AHL production and is required for plant colonization3CDL40
AguRPseudomonas aeruginosa PAO1Regulates AguBA required for agmatine utilizationAgmatine181
AlnR2Streptomyces sp. strain CM020Located in the alnumycin biosynthesis cluster220
AlpWStreptomyces ambofaciensLocated in the alpomycin biosynthesis cluster and involved in the regulation of kinamycin biosynthesis; similar to gamma-butyrolactone receptors221
AlpZStreptomyces ambofaciensLocated in the alpomycin biosynthesis cluster; similar to gamma-butyrolactone receptors222
AmeRAgrobacterium tumefaciensRegulates the tripartite RND exporter AmeABC223
AmiPStreptomyces vinaceus-drappusLocated in the amicetin biosynthesis cluster95
AmtRCorynebacterium glutamicumGlobal regulator of nitrogen control metabolismGlnK37
Ang8Streptomyces sp. strain W007Located in an angucyclinone biosynthesis cluster224
ArpAStreptomyces griseusInvolved in the regulation of antibiotic production and sporulationA-factor (GBL)225
ArpRPseudomonas putida S12Regulates the ArpABC efflux pump involved in the export of multiple antibiotics226
Asm2Actinosynnema pretiosumLocated in the ansamitocin biosynthesis cluster and involved in the regulation of ansamitocin biosynthesis227
Asm29Actinosynnema pretiosumLocated in the ansamitocin biosynthesis cluster and involved in the regulation of ansamitocin biosynthesis227
AtrAStreptomyces coelicolorPleiotropic regulator of antibiotic biosynthesis6
AtuRPseudomonas aeruginosaRegulates genes required for acyclic terpene utilization174
Aur1BStreptomyces aureofaciens CCM 3239Located in the auricin biosynthesis cluster228
Aur1RStreptomyces aureofaciens CCM 3239Located in the auricin biosynthesis cluster; similar to gamma-butyrolactone receptors229
AvaR1Streptomyces avermitilisRegulator of avermectin biosynthesis; similar to gamma-butyrolactone receptorsAvenolide127
AvaR2Streptomyces avermitilisSimilar to gamma-butyrolactone receptors230
AvaR3Streptomyces avermitilisPleiotropic regulator of antibiotic production; similar to gamma-butyrolactone receptors230
AveIStreptomyces avermitilisOrtholog of AtrA; regulator of antibiotic production231
Azi42Streptomyces sahachiroiLocated adjacent to the azinomycin B biosynthetic gene cluster; thought to be beyond the boundaries of the cluster232
BarAStreptomyces virginiaeInvolved in the regulation of virginiamycin; similar to gamma-butyrolactone-binding proteinsVirginiae butanolide (GBL)233
BarBStreptomyces virginiaeInvolved in the regulation of virginiamycin; similar to gamma-butyrolactone-binding proteins234
BarZStreptomyces virginiaeLocated in the virginiamycin biosynthesis cluster; similar to gamma-butyrolactone-binding proteins235
BdcR (YjgJ)Escherichia coliRegulator of BdcA expression28
BecMStreptomyces sp. strain DSM 21069Located in the biosynthesis cluster for macrolactam BE-14106 biosynthesis236
BepRBrucella suisRegulator of the BepDE efflux pumpDeoxycholate237
BetIEscherichia coliRegulates expression of BetT, BetA, and BetB required for the synthesis of glycine betaine from cholineCholine238
BioQCorynebacterium glutamicum ATCC 13032Regulates biotin biosynthesis and import189
BpeRBurkholderia pseudomalleiRegulates the BpeAB-OprB multidrug efflux pump239
BreRVibrio choleraeRegulates the BreAB efflux pump in response to bileDeoxycholate39
BrpStreptomyces clavuligerusGamma-butyrolactone receptor involved in the regulation of clavulanic acid and cephamycin C biosynthesis240
BrtAListeria monocytogenesRegulator of the MdrT efflux pumpCholate241
BspRBurkholderia pseudomalleiInvolved in regulating type III secretion systems242
BtrR1Bacillus circulansLocated in the butirosin biosynthesis cluster and involved in regulation243
CalR1Micromonospora echinosporaLocated in the calicheamicin biosynthesis cluster244
CampRRhodococcus sp. strain NCIMB 9784Divergent to camK (6-oxocamphor hydrolase)177
CamRPseudomonas putidaRegulator of camphor degradation245
CasRRhizobium etliRegulator of CasA required for colonization and infection of the host246
CgmR (cg2894, Cgl2612)Corynebacterium glutamicumMultidrug resistance-related transcription factorEthidium bromide, malachite green2ZOY, 2ZOZ, 2YVH, 2YVE43, 247
ChlF1Streptomyces antibioticusLocated in the chlorothricin biosynthetic gene cluster248
ChryX5Streptomyces albaduncusLocated in the chrysomycin biosynthesis cluster; a homolog is not present in the cluster for the related molecule ravidomycin249
CifRPseudomonas aeruginosaRegulator of the Cif toxinEpibromohydrin250
CmeRCampylobacter jejuniRegulator of the CmeABC efflux pumpTaurocholate, cholate, salicylate2QCO, 3QPS, 3QQA56
CmtIPseudomonas putidaPutative regulator of operons required for p-cymene/p-cumate degradation175
CmtRPseudomonas putidaPutative regulator of operons required for p-cymene/p-cumate degradation178
ComREscherichia coliRegulator of ComC involved in copper permeabilityCopper72
CprAStreptomyces coelicolorSimilar to gamma-butyrolactone receptors; involved in regulating sporulation and antibiotic production134
CprBStreptomyces coelicolorSimilar to gamma-butyrolactone receptors; involved in regulating sporulation and antibiotic production1IU5, 1IU6134
CprSStreptomyces coelicolorSimilar to gamma-butyrolactone receptors251
CymRPseudomonas putidaRegulator of the cym and cmt operons required for p-cymene and p-cumate degradationp-Cumate176
DarR (MSMEG_5346)Mycobacterium smegmatisFirst cyclic-di-AMP-responsive transcription factor to be identified in bacteriaCyclic-di-AMP142
DddHHalomonas sp. strain HTNK1Putative regulator of genes required for dimethylsulfoniopropionate and acrylate catabolism252
DesTPseudomonas aeruginosaRegulates the expression of the DesCB acyl-CoA desaturase operonOleate (corepressor), stearate (inducer)3LSJ, 3LSR, 3LSP166
DhaRRhodococcus rhodochrousRegulator of haloalkane dehalogenase (DhaA)143
DhaSLactococcus lactisRegulator of the dha operon; functions as a transcriptional activatorDhaQ-dihydroxyacetone complex2IU569
EbrRStreptomyces lividansRegulator of the EbrA efflux pump3HTJ, 3HTI, 3HTH, 3HTA253
EbrSStreptomyces lividansRegulator of the EbrC efflux pump254
Ecm10Streptomyces lasaliensisLocated in the echinomycin biosynthesis cluster255
EmhRPseudomonas fluorescensRegulates the EmhABC efflux pump that influences production of 2,4-diacetylphloroglucinol and is required for phenanthrene, anthracene, and fluoranthene efflux256, 257
EncSStreptomyces maritimusLocated in the enterocin biosynthesis gene cluster258
EnvR (AcrS)Escherichia coliDivergent to the AcrEF efflux pump; may function as a switch for the alternative expression of AcrAB and AcrEF efflux pumps259
EpeRStreptomyces clavuligerusControls expression of the EpeA efflux pump260
EsmT4Streptomyces antibioticus Tu 2706Located in the esmeraldin biosynthesis cluster261
EthRMycobacterium tuberculosisRegulator of ethA encoding a monooxygenase required for the activation of ethionamideHexadecyl octanoate1T5658
FabREscherichia coliRegulator of genes required for unsaturated fatty acid synthesisUnsaturated thioesters165
Fad35R (Rv2506)Mycobacterium tuberculosisRegulator of Fad35 acyl-CoA synthetasePalmitoyl-CoA162
FadR (YsiA)Bacillus subtilisRegulator of fatty acid catabolismLong-chain acyl-CoAs1VIO161
FadRPseudonocardia autotrophicaRegulates fad genes required for fatty acid degradation158
FadRThermus thermophilusRegulator of genes required for fatty acid degradationMedium to long (C10 to C18) straight-chain fatty acyl-CoAs3ANG, 3ANP150
FarAStreptomyces sp. strain FRI-5Gamma-butyrolactone autoregulator that controls antibiotic productionIM-2 (GBL)262
FasRCorynebacterium glutamicumRegulator of accD1 and fasA expression required for lipid synthesis157
FrrABradyrhizobium japonicumRegulator of the FreABC efflux pumpGenistein, daidzein263
HapRVibrio choleraeMaster quorum-sensing regulator2PBX264
HemRPropionibacterium freudenreichiiPossible regulator of hem gene expression required for the conversion of glutamate to protoheme190
HlyIIRBacillus cereusRegulator of hemolysin II expression265
HnoR (HdnoR)Arthrobacter nicotinovoransRepressor of 6-hydroxy-d-nicotine oxidase6-Hydroxy-d- and 6-hydroxy-l-nicotine266
HrtRLactococcus lactisRegulator of the HrtB-HtrA transporterHeme3VP5, 3VP5, 3VOX191, 46
IcaRStaphylococcus epidermidisRegulator of the ica operon required for biofilm formation2ZCM, 2ZCN267
IfeRAgrobacterium tumefaciensRegulator of the IfeAB efflux pump268
JadR*Streptomyces venezuelaeLocated in the jadomycin biosynthesis cluster269
JadR2Streptomyces venezuelaeSimilar to gamma-butyrolactone receptors; involved in the regulation of jadomycin biosynthesisJadomycin and chloramphenicol133, 270
KanGStreptomyces kanamyceticusLocated near the kanamycin biosynthesis cluster but probably beyond cluster boundaries271
KijA8Actinomadura kijaniataLocated in the kijanimicin biosynthesis clusterKijanimicin272
KijC5Actinomadura kijaniataLocated in the kijanimicin biosynthesis cluster272
KijRStreptomyces coelicolorRegulator of KijX expression and kijanimicin resistanceKijanimicin, saccharocarcins A and B25
KinRStreptomyces murayamaensisLocated in the kinamycin biosynthesis cluster273
KirRIIStreptomyces collinusLocated in the kirromycin biosynthesis cluster274
KsbAKitasatospora setaeGamma-butyrolactone receptor protein; involved in regulating bafilomycin biosynthesisGBLs275
KstRMycobacterium tuberculosisRegulator of lipid metabolism3MNL169
KstR2Mycobacterium tuberculosisRegulator of cholesterol metabolism170
LanKStreptomyces cyanogenusLocated in the landomycin biosynthetic pathwayLandomycin A and intermediates78
Lct13Streptomyces rishiriensisPutative gamma-butyrolactone receptor protein; located in the lactonamycin biosynthesis cluster276
Lct14Streptomyces rishiriensisPutative gamma-butyrolactone receptor protein; located in the lactonamycin biosynthesis cluster276
LfrRMycobacterium smegmatisRegulator of LfrA multidrug efflux pumpProflavine2WGB, 2V5755
LitRVibrio fischeriInvolved in regulating luminescence and symbiotic light organ colonization277
LiuQ (Bamb_4589)Burkholderia ambifaria AMMDRegulator of branched-chain amino acid degradation183
LmrABacillus subtilisRegulator of the LmrB efflux pumpFlavonoids (quercetin, fisetin, galangin, catechin, coumestrol, genistein)104
LplRRhodococcus erythropolisRegulator of l-pantoyl lactone dehydrogenase gene expression278
LuxRVibrio harveyiGlobal regulator279
LuxTVibrio harveyiGlobal regulator280
McbRCorynebacterium glutamicumGlobal regulator of l-methionine and l-cysteine biosynthesisS-Adenosylhomocysteine185
Mce3RMycobacterium tuberculosisPutative regulator of lipid metabolism281
MdoRMycobacterium sp. strain JC1Regulator of genes required for methanol oxidation147
MedORF28Streptomyces sp. strain AM-7161Located in the medermycin biosynthesis cluster282
MepRPseudomonas putidaRegulates efflux pump involved in toluene resistance283
MerOStreptomyces sp. strain NRRL 30748Located in the meridamycin biosynthesis cluster284
MexLPseudomonas aeruginosaRegulator of the MexJK efflux pump285
MexZ (AmrR)Pseudomonas aeruginosaRegulates the MexXY (AmrAB) exporter involved in aminoglycoside resistance2WUI286
MlaMStreptomyces sp. strain MP39-85Located in the biosynthetic gene cluster for the macrocyclic lactam ML-44992
MmfRStreptomyces coelicolorGamma-butyrolactone-like receptor involved in regulating methylenomycin production128, 287
MmyRStreptomyces coelicolorGamma-butyrolactone-like receptor involved in regulating methylenomycin production128, 287
MmyRStreptomyces violaceoruberLocated in the methylenomycin biosynthesis cluster288
MnbRComamonas sp. strain JS46Putative regulator of mnb operon required for 3-nitrobenzoate oxidation144
MonRIIStreptomyces cinnamonensisLocated in the monensin biosynthesis locus289
MphREscherichia coliRegulator of macrolide resistance14-membered macrolides (erythromycin, oleandomycin)3G56, 3FRQ101
MSMEG_6564Mycobacterium smegmatisGlobal regulator of DNA repair genes290
MtrRNeisseria gonorrhoeaeRegulator of the mtr efflux pump3VIB291
NalCPseudomonas aeruginosaIndirect regulator of the MexAB-OprM efflux pump through regulation of ArmR expressionChlorinated phenols292, 293, 294, 295
NalDPseudomonas aeruginosaRegulator of the MexAB-OprM efflux pump296
NapR3Streptomyces aculeolatusLocated in the napyradiomycin biosynthesis cluster297
NapR7Streptomyces aculeolatusLocated in the napyradiomycin biosynthesis cluster297
NcsR2Streptomyces carzinostaticusGamma-butyrolactone receptor located in the neocarzinostatin biosynthesis cluster298
NcsR3Streptomyces carzinostaticusGamma-butyrolactone receptor located in the neocarzinostatin biosynthesis cluster298
NcsR4Streptomyces carzinostaticusLocated in the neocarzinostatin biosynthesis cluster298
NemR (YdhM)Escherichia coliRegulator of N-ethylmaleimide reductaseN-Ethylmaleimide and other Cys modification reagents299
NfxBPseudomonas aeruginosaRegulator of the MexCD-OprJ efflux pump300
NicSPseudomonas putidaRegulator of genes required for nicotinic acid degradationNicotinic acid and hydroxynicotinic acid148
NonGStreptomyces griseusLocated near the nonactin biosynthesis cluster but probably beyond cluster boundaries301
OpaRVibrio parahaemolyticusGlobal regulator301
ORF20pStreptomyces hygroscopicusLocated in the geldanamycin biosynthesis locus
OrfH2Streptomyces griseoruberLocated in the hedamycin biosynthesis locus302
OvmYStreptomyces antibioticusLocated in the oviedomycin biosynthesis cluster303
PaaRAzoarcus evansiiRegulator of genes required for phenyl acetic acid degradation304
PaaRThermus thermophilusRegulator of genes required for phenyl acetic acid degradationPhenylacetyl coenzyme A150
PapR3Streptomyces pristinaespiralisLocated in the pristinamycin biosynthesis cluster; similar to gamma-butyrolactone receptors305
PapR5Streptomyces pristinaespiralisLocated in the pristinamycin biosynthesis cluster; similar to gamma-butyrolactone receptors305
PG1181Porphyromonas gingivalisExpressed in response to NO stress306
PgaYStreptomyces sp. strain PGA64Located in the pga angucyclinone biosynthesis cluster307
PhaDPseudomonas putidaRegulator of genes required for polyhydroxyalkanoate metabolism167
PhlFPseudomonas fluorescensLocated in the 2,4-diacetylphloroglucinol biosynthesis cluster2,4-Diacetylphloroglucinol (inducer), salicylate (corepressor)75
PhlHPseudomonas fluorescensLocated in the 2,4-diacetylphloroglucinol biosynthesis cluster308
PigZSerratia sp. strain ATCC 39006Regulator of the ZrpADBC efflux pump309
Pip (SCO4025)Streptomyces coelicolorRegulator of the Pep efflux pumpPristinamycin I100
PksABacillus subtilisLocated in the bacillaene biosynthesis cluster310
PlaR2Streptomyces sp. strain Tü6071Located in the phenalinolactone biosynthesis cluster311
PltZPseudomonas sp. strain M18Located in the pyoluteorin biosynthesis cluster312
PmeR (PSPTO_4302)Pseudomonas syringaeRegulator of MexAB-OprMFlavonoids313
PqrA (SCO1568)Streptomyces coelicolorRegulator of the PqrB efflux pump314
PsbIRhodopseudomonas palustrisRegulator of p-cumate catabolismp-Cumate179
PsrAPseudomonas aeruginosaRegulator of the β-oxidation operonLong-chain fatty acids2FBQ163
PydRPseudomonas putida KT2440Regulator of pyrimidine reductive catabolic pathway154
Pyr27Actinosporangium vitaminophilumLocated in the pyrrolomycin biosynthesis cluster315
Pyr3Actinosporangium vitaminophilumLocated in the pyrrolomycin biosynthesis cluster315
PyrOStreptomyces pyridomyceticusLocated in the pyridomycin biosynthesis cluster; similar to gamma-butyrolactone receptors316
QacRStaphylococcus aureusRegulator of the QacA efflux pumpRhodamine 6G, dequalinium, crystal violet, berberine, DiOC3, methyl green, benzalkonium, tetraphenylarsonium, nitidine, palmatine1JTX, 1JT6, 1JTY, 1JUM, 1JUP, 1JUS, 1JTO, 1QVT, 1QVU60, 53
QdoR (YxaF)Bacillus subtilisRegulator of quercetin dioxygenase QdoI (YxaG)Flavonoids (quercetin, fisetin, tamarixetin, galangin, genistein, coumestrol)317
RamR (STM0580)Salmonella enterica serovar TyphimuriumRegulator of the RamA efflux pump; mutations in the RamR binding site result in a multidrug resistance phenotype318
RefZ (YttP)Bacillus subtilisInvolved in the switch from medial to polar cell division195
RegEActinoplanes friuliensisLocated in (or adjacent to) the friulimicin biosynthesis cluster319
RemMStreptomyces resistomycificusLocated in the resistomycin biosynthesis cluster320
RemQStreptomyces resistomycificusLocated in the resistomycin biosynthesis cluster320
RifQAmycolatopsis mediterraneiLocated in the rifamycin biosynthesis cluster91
RkIStreptomyces strain sp. 88-682Located in the RK-682 biosynthesis cluster321
RmiRRhizobium etliRegulator of NodTch322
RmrRRhizobium etliRegulator of the RmrAB efflux pump323
RolRCorynebacterium glutamicumRegulator of resorcinol degradationResorcinol3AQS, 3AQT49
RphA3Streptomyces griseoviridisLocated in the prodigiosin biosynthesis cluster324
RrdA (SCO1104)Streptomyces coelicolorRegulator of antibiotic production325
RutR (YcdC)Escherichia coliRegulator of pyrimidine synthesisUracil326
Rv3066Mycobacterium tuberculosisRegulator of Mmr multidrug efflux pumpEthidium3V6G, 3V78327
SaaRStreptomyces ambofaciensGamma-butyrolactone receptor involved in regulating spiramycin production328
SabRStreptomyces ansochromogenesGamma-butyrolactone receptor involved in regulating nikkomycin production329
SabRStreptomyces acidiscabiesGamma-butyrolactone receptor involved in regulating WS5995B production330
SabSStreptomyces acidiscabiesGamma-butyrolactone receptor involved in regulating WS5995B production330
SACE_7040Saccharopolyspora erythraeaRegulator of morphological differentiation331
SaqKMicromonospora sp. strain Tu 6368Located in the saquayamycin Z biosynthesis cluster83
SAV3818Streptomyces avermitilisGlobal upregulator of antibiotic production in Streptomyces species332
SbtRThermus thermophilus HB8Contains an intermolecular disulfide bridge that may be involved in ligand affinity3VUQ333
SCAB1401Streptomyces scabiesLocated in the pyochelin biosynthesis cluster334
ScbRStreptomyces coelicolorGamma-butyrolactone-binding protein; pleiotropic regulator of antibiotic productionSCB1251
ScbR2Streptomyces coelicolorSimilar to gamma-butyrolactone-binding proteins; regulator of Cpk polyketide production and gamma-butyrolactone biosynthesisActinorhodin and undecylprodigiosin131, 132, 133
SchA21Streptomyces sp. strain SCC-2136Located in the biosynthesis cluster for the angucyclinones Sch 47554 and Sch 47555335
SchA4Streptomyces sp. strain SCC-2136Located in the biosynthesis cluster for the angucyclinones Sch 47554 and Sch 47555335
SchR3Streptomyces chartreusisLocated in the biosynthesis cluster for calcimycin (A23187)93
SCO0253Streptomyces coelicolorRegulator of SCO0252Tetracycline3FIW336
SCO0332Streptomyces coelicolorRegulator of SCO03302ZB9337
SCO1712Streptomyces coelicolorRegulator of antibiotic production3BNI338, 160
SCO3201Streptomyces coelicolorRegulator of antibiotic production339
SczAStreptococcus pneumoniaeRegulator of metal ion homeostasisZn2+71
SfmR1Streptomyces lavendulaeLocated in the saframycin A biosynthesis cluster340
SimRStreptomyces antibioticusLocated in the simocyclinone D8 biosynthesis clusterSimocyclinones D8 and C42Y2Z, 2Y30, 2Y3176
SlgR1Streptomyces lydicusLocated in the streptolydigin biosynthesis cluster341
SlmAEscherichia coliNucleoid occlusion factorFtsZ3NXC192, 193
SmcRVibrio vulnificusGlobal regulator3KZ9342, 343
SmeTStenotrophomonas maltophiliaRegulator of the SmeDEF efflux pumpTriclosan2W5352, 61, 344
SMU_1349Streptococcus mutansRegulator of the TnSmu2 operon, which contains a secondary metabolite biosynthesis gene cluster345, 346
SngRStreptomyces natalensisGamma-butyrolactone receptor protein involved in regulating natamycin biosynthesis and sporulation347
SocA3Myxococcus xanthusInvolved in regulating morphological development348
SpbRStreptomyces pristinaespiralisGamma-butyrolactone receptor protein involved in regulating pristinamycin biosynthesis and sporulation349, 305
SrpRPseudomonas putidaRegulator of the SrpABC efflux pumpSrpS350, 351
SrrAStreptomyces rocheiGamma-butyrolactone receptor protein involved in regulating lankacidin and lankamycin biosynthesis and sporulation352, 353
SrrBStreptomyces rocheiGamma-butyrolactone receptor protein involved in regulating lankacidin and lankamycin biosynthesis and sporulation352
SrrCStreptomyces rocheiGamma-butyrolactone receptor protein involved in regulating lankacidin and lankamycin biosynthesis and sporulation352
SscRStreptomyces scabiesGamma-butyrolactone receptor protein involved in regulating secondary metabolismGBLs354
SsfT2Streptomyces sp. strain SF2575Located in the biosynthesis cluster for the polyketide SF257599
Strop_2766Salinispora tropicaLocated in the salinilactam biosynthesis cluster355
TamKStreptomyces sp. strain 307-9Located in the tirandamycin biosynthesis cluster356
SwrTVibrio parahaemolyticusOrtholog of V. harveyi LuxT; regulator of swarming motility357
TarAStreptomyces tendaeGamma-butyrolactone receptor protein involved in regulating nikkomycin production358
TcaR2Micromonospora chalceaLocated in the tetrocarcin A biosynthesis cluster359
TcmRStreptomyces glaucescensLocated in the tetracenomycin C biosynthesis cluster360
Tei8Actinoplanes teichomyceticusLocated in the teicoplanin biosynthesis cluster361
TetREscherichia coliRegulator of tetracycline resistanceTetracycline2TCT, 1QPI362
TetRArthrobacter oxydansPutative regulator of genes required for phenyl acetic acid degradation363
TetRStreptomyces toxytriciniPutative regulator of the propionyl-CoA carboxylase complex364
Tmn21Streptomyces sp. strain NRRL 11266Located in the tetronomycin biosynthesis cluster365
TRMycobacterium peregrinumPutative regulator of macrolide resistance366
TrdKStreptomyces sp. strain SCSIO1666Located in the tirandamycin biosynthesis cluster367
Tsn22Streptomyces longisporoflavusLocated in the tetronasin biosynthesis clusterGenBank accession no. FJ462704
TtgRPseudomonas putidaRegulator of the TtgABC efflux pumpPhloretin, naringenin, chloramphenicol, tetracycline, quercetin, luteolin2UXP, 2UXI, 2UXH, 2UXU, 2UXO51, 368, 369
TtgWPseudomonas putidaDivergent to the TtgGHI efflux pump but does not play a major role in regulation370
TvrRPseudomonas syringaeRequired for pathogenesis371
TylPStreptomyces fradiaeGamma-butyrolactone receptor protein involved in regulating tylosin production and sporulation372, 373
TylQStreptomyces fradiaeGamma-butyrolactone receptor protein involved in regulating tylosin production373
UidREscherichia coliRegulator of the d-glucuronidase UidA374
UrdKStreptomyces fradiaeLocated in the urdamycin biosynthesis cluster84
VanTVibrio (Listonella) anguillarumGlobal regulator375
VarRStreptomyces virginiaeLocated in the virginiamycin biosynthesis clusterVirginiamycin S77
VceRVibrio choleraeRegulator of VceCAB efflux pumpCarbonyl cyanide m-chlorophenyl hydrazone376
VexRVibrio choleraeRegulates the VexAB efflux pump which is expressed in response to bile, sodium dodecyl sulfate, or novobiocin39
VlmEStreptomyces viridifaciensLocated in the valanimycin biosynthesis cluster377
VtpRVibrio tubiashiiGlobal regulator of virulence factors378
XdhR (SCO1135)Streptomyces coelicolorRegulator of xanthine dehydrogenase156
  • a MFS, major facilitator superfamily; AHL, acyl-homoserine lactone.