TABLE 1

Bioinformatic comparison of genes involved in homologous recombination, nonhomologous end joining, and microhomology-mediated end joining among S. cerevisiae, H. sapiens, and P. falciparum

Repair mechanismGene product or PlasmoDB ID
S. cerevisiaeH. sapiensP. falciparumd
Homologous recombinationMre11MRE11PF3D7_0107800
Rad50RAD50PF3D7_0605800
Xrs2NBS1
Sae2CtIP
Exo1EXO1PF3D7_0725000
Sgs1BLMPF3D7_0918600
WRNPF3D7_1429900a
Top3TopoIIIαPF3D7_1347100
Rmi1RMI1
Dna2DNA2PF3D7_1010200
Rfa1RPA1PF3D7_0409600, PF3D7_0904800
Rfa2RPA2
Rfa3RPA3
Rad51RAD51PF3D7_1107400
Dmc1DMC1PF3D7_0816800
Rad52RAD52
BRCA2PF3D7_1328200b
Rad54RAD54PF3D7_0803400
DNA polymerase δDNA polymerase δPF3D7_1017000
PCNAPCNAPF3D7_1361900 (PCNA 1)
PF3D7_1226600 (PCNA 2)
Srs2RTEL1PF3D7_0514100c
Rad1XPFPF3D7_1368800
Rad10ERCC1PF3D7_0203300
Mus81MUS81PF3D7_1449400
Mms4EME1
Yen1GEN1PF3D7_0206000
Spo11SPO11PF3D7_1217100
Nonhomologous end joiningKu70Ku70
Ku80Ku80
Dnl4DNA ligase IV
DNA-PKcs
Artemis
Lif1XRCC4
Nej1Cernunnos/XLF
Microhomology-mediated end joiningMre11MRE11PF3D7_0107800
Rad50RAD50PF3D7_0605800
Xrs2NBS1
Sae2CtIP
Tel1ATM
Rad1XPFPF3D7_1368800
Rad10ERCC1PF3D7_0203300
Rad27FEN1PF3D7_0408500
Cdc9DNA ligase IPF3D7_1304100
Rev3DNA Pol ζ catalytic subunitPF3D7_1037000
Pol4DNA Pol β
Rad30DNA Pol η
  • a Lacks 5′-to-3′ exonuclease indicative of WRN.

  • b Low homology.

  • c Possible UvrD helicase.

  • d P. falciparum orthologs were determined from previous publications or were confirmed by BLAST and identification of unique domains with Pfam, version 27.0.