TABLE 2

Apicomplexan-specific cyclophilins

GroupOrganismProtein (gene accession no.)LocalizationaAdditional domain(s) and function(s)b
Small apicomplexan-specific cyclophilinsB. bovisBbCyp28.6 (5477723)CytoplasmC-terminal extension with no known homology
P. falciparumPfCyp26.4 (811077)CytoplasmC-terminal extension with no known homology
T. parvaTpCyp20.3 (3502670)CytoplasmND
T. gondiiTgCyp31.8 (052840)MitochondrionN-terminal mitochondrial localization signal, C-terminal extension with no known homology
Apicoplast-specific cyclophilinsTheileria annulataTaCyp25.7 (3864051)ApicoplastN-terminal apicoplast localization signal
T. parvaTpCyp25.5 (3502505)ApicoplastN-terminal apicoplast localization signal
Plasmodium-specific cyclophilinsP. falciparumPfCyp72.5 (813578)NucleusMultiple nuclear localization signals, N-terminal RNP motif for RNA binding, internal coiled-coil protein interaction domains
P. yoeliiPyCyp69.8 (3830381)NucleusMultiple nuclear localization signals, internal coiled-coil protein interaction domains
  • a Predicted.

  • b Putative. ND, not determined.