TABLE 1

Correlation coefficients of resistance to different drugs used to treat Streptococcus pneumoniae infections in the United Statesa

Period (n)DrugCorrelation coefficentb
ERYTETCLISXTTAXCAZLVX
Pre-PCV7 (7,571)PEN0.610***0.370***0.266***0.700***0.454***0.037**
ERY0.427***0.399***0.574***0.311***0.015
TET0.574***0.338***0.173***0.009
CLI0.229***0.078***0.037**
SXT0.397***0.029*
TAX0.021
Intermediate PCV7 coverage (16,735)PEN0.613***0.359***0.288***0.626***0.437***0.299***0.026***
ERY0.427***0.440***0.559***0.369***0.291***0.045***
β-TET0.668***0.321***0.230***0.291***0.052***
CLI0.234***0.198***0.301***0.040***
SXT0.389***0.277***0.035***
TAX0.727***0.026***
CAZ−0.011
High PCV7 coverage (6,785)PEN0.579***0.460***0.422***0.576***0.440***0.326***0.030*
ERY0.565***0.577***0.588***0.443***0.338***0.049***
TET0.819***0.399***0.516***0.415***0.026*
CLI0.343***0.516***0.393***0.035**
SXT0.454***0.336***0.045***
TAX0.727***0.014
CAZ0.019
  • a PCV7, 7-valent pneumococcal conjugate vaccine; PEN, penicillin; ERY, erythromycin; TET, tetracycline; CLI, clindamycin; SXT, trimethoprim-sulfamethoxazole; TAX, cefotaxime; CAZ, ceftazidime; LVX, levofloxacin.

  • b ***, P < 0.001; **, P < 0.01; *, P < 0.1.