TABLE 2

SMases and PLases for which there are in vivo data supporting a role in bacterial virulence

SpeciesEnzyme nameEnzyme classDisease modelReference(s)
Staphylococcus aureusBeta-toxinSphingomyelinase CPneumonia46
Endocarditis45
Skin infection43
Bacillus cereusSMase CSphingomyelinase CSepticemia33, 36
Listeria ivanoviiSMase CSphingomyelinase CSystemic infection38
Corynebacterium pseudotuberculosisSMase DSphingomyelinase D which adopts a TIM barrel structureLymphadenitis56, 65
Photobacterium damsealeDamselysinOther sphingomyelinase DsSystemic infection66, 67
Yersinia pseudotuberculosisPldAAcyl hydrolase which adopts an antiparallel β-barrel structureGastroenteritis73
Legionella pneumophilaPlaBSurface-associated PLA2Pneumonia86
Salmonella entericaSseJAcyl hydrolase from the SGNH esterase family PLASystemic infection98, 102, 104, 105
Yersinia enterocoliticaYplAAcyl hydrolase which adopt the α/β hydrolase foldGastroenteritis106
Pseudomonas aeruginosaExoUSecreted patatin-like acyl hydrolase, PLAPneumonia132, 152, 160, 162
Pneumosepsis161
Keratitis153
Streptococcus pyogenesSlaAClass XIB PLA2Pharyngitis178
Listeria monocytogenesPI-PLCPI-PLCSystemic infection194
PI-PLC, PlcBPI-PLC, Zn2+ metalloPLCSystemic infection187
PlcBZn2+ metalloPLCMeningoencephalitis207
Bacillus anthracisSMase C, PI-PLC, PC-PLCSMase C, PI-PLC PC preferring Zn2+ metalloPLCPulmonary infection37
Clostridium perfringensalpha-toxinZn2+ metalloPLCGas gangrene218, 219, 221
Necrotic enteritis240, 241, 242
Pseudomonas aeruginosaPlcHPLC from the acid phosphatase superfamilySystemic infection252, 253
Pulmonary infection258
Mycobacterium abscessusPLCPLC from the acid phosphatase superfamilyPulmonary infection272, 273
Burkolderia pseudomalleiPLCPLC from the acid phosphatase superfamilySystemic infection266
Rickettsia prowazekiiPLDPLDSystemic infection289
Acinetobacter baumanniiPLDPLDPneumonia286
Klebsiella pneumoniaePLDPLDPneumonia302
Legionella pneumophilaLpdAPLDPneumonia280