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curli

  • Emerging Roles of Functional Bacterial Amyloids in Gene Regulation, Toxicity, and Immunomodulation
    Review
    Emerging Roles of Functional Bacterial Amyloids in Gene Regulation, Toxicity, and Immunomodulation

    Bacteria often reside in multicellular communities, called biofilms, held together by an extracellular matrix. In many bacteria, the major proteinaceous component of the biofilm are amyloid fibers. Amyloids are highly stable and structured protein aggregates which were known mostly to be associated with neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. In recent years, microbial amyloids were...

    Nir Salinas, Tatyana L. Povolotsky, Meytal Landau, Ilana Kolodkin-Gal
  • Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications
    Review
    Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications

    Biofilms of enteric bacteria are highly complex, with multiple components that interact to fortify the biofilm matrix. Within biofilms of enteric bacteria such as Escherichia coli and Salmonella species, the main component of the biofilm is amyloid curli. Other constituents include cellulose,...

    Sarah A. Tursi, Çagla Tükel
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